Efficacy/Safety of DP-R207 Tablet Versus CRESTOR Tablet in Patients With Primary Hypercholesterolemia

NCT ID: NCT02445352

Last Updated: 2015-05-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

379 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-07-31

Study Completion Date

2015-03-31

Brief Summary

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The purpose of this study is to evaluate efficacy and safety of DP-R207 in patients with primary hypercholesterolemia.

Detailed Description

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Conditions

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Primary Hypercholesterolemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Rosuvastatin 5mg & Placebo & Placebo

Once a day, administration of rosuvastatin 5mg and two types of placebo for 20 weeks

Group Type ACTIVE_COMPARATOR

Rosuvastatin 5mg

Intervention Type DRUG

Placebo (for Rosuvastatin 10mg and DP-R207 10/10mg)

Intervention Type DRUG

Placebo (for Rosuvastatin 20mg and DP-R207 20/10mg)

Intervention Type DRUG

DP-R207 5/10mg & Placebo & Placebo

Once a day, administration of DP-R207 5/10mg and two types of placebo for 20 weeks

Group Type EXPERIMENTAL

DP-R207 5/10mg

Intervention Type DRUG

Placebo (for Rosuvastatin 10mg and DP-R207 10/10mg)

Intervention Type DRUG

Placebo (for Rosuvastatin 20mg and DP-R207 20/10mg)

Intervention Type DRUG

Rosuvastatin 10mg & Placebo & Placebo

Once a day, administration of rosuvastatin 10mg and two types of placebo for 20 weeks

Group Type ACTIVE_COMPARATOR

Rosuvastatin 10mg

Intervention Type DRUG

Placebo (for Rosuvastatin 5mg and DP-R207 5/10mg)

Intervention Type DRUG

Placebo (for Rosuvastatin 20mg and DP-R207 20/10mg)

Intervention Type DRUG

DP-R207 10/10mg & Placebo & Placebo

Once a day, administration of DP-R207 10/10mg and two types of placebo for 20 weeks

Group Type EXPERIMENTAL

DP-R207 10/10mg

Intervention Type DRUG

Placebo (for Rosuvastatin 5mg and DP-R207 5/10mg)

Intervention Type DRUG

Placebo (for Rosuvastatin 20mg and DP-R207 20/10mg)

Intervention Type DRUG

Rosuvastatin 20mg & Placebo & Placebo

Once a day, administration of rosuvastatin 20mg and two types of placebo for 20 weeks

Group Type ACTIVE_COMPARATOR

Rosuvastatin 20mg

Intervention Type DRUG

Placebo (for Rosuvastatin 5mg and DP-R207 5/10mg)

Intervention Type DRUG

Placebo (for Rosuvastatin 10mg and DP-R207 10/10mg)

Intervention Type DRUG

DP-R207 20/10mg & Placebo & Placebo

Once a day, administration of DP-R207 20/10mg and two types of placebo for 20 weeks

Group Type EXPERIMENTAL

DP-R207 20/10mg

Intervention Type DRUG

Placebo (for Rosuvastatin 5mg and DP-R207 5/10mg)

Intervention Type DRUG

Placebo (for Rosuvastatin 10mg and DP-R207 10/10mg)

Intervention Type DRUG

Interventions

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Rosuvastatin 5mg

Intervention Type DRUG

DP-R207 5/10mg

Intervention Type DRUG

Rosuvastatin 10mg

Intervention Type DRUG

DP-R207 10/10mg

Intervention Type DRUG

Rosuvastatin 20mg

Intervention Type DRUG

DP-R207 20/10mg

Intervention Type DRUG

Placebo (for Rosuvastatin 5mg and DP-R207 5/10mg)

Intervention Type DRUG

Placebo (for Rosuvastatin 10mg and DP-R207 10/10mg)

Intervention Type DRUG

Placebo (for Rosuvastatin 20mg and DP-R207 20/10mg)

Intervention Type DRUG

Other Intervention Names

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Rosuvastatin 5mg Ezetimibe 10mg Rosuvastatin 10mg Ezetimibe 10mg Rosuvastatin 20mg Ezetimibe 10mg

Eligibility Criteria

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Inclusion Criteria

* Aged over 19 years
* Signed informed consent form
* At visit 1 and visit 2, LDL-Cholesterol ≤ 250mg/dL and Triglyderide ≤ 350mg/dL

Exclusion Criteria

* Has a history of hypersensitivity to HMG-CoA reductase inhibitor and component of ezeimibe
* Liver transaminases \> 2 x upper limit of normal
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alvogen Korea

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yangsoo Jang, Ph.D.

Role: STUDY_CHAIR

Severance Hospital

Locations

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Severance Hospital

Seodaemun-gu, Seoul, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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DP-CTR207-III-02

Identifier Type: -

Identifier Source: org_study_id

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