Swept Source Enhanced Depth Imaging Optical Coherence Tomography

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-31

Study Completion Date

2019-08-31

Brief Summary

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The investigators would be interested in applying the enhanced depth imaging technique to swept source optical coherence tomography, by modifying the acquisition protocol. Doing so, the investigators hope to improve the visualization of the choroid and perhaps even of the sclera.

Detailed Description

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A structurally and functionally normal choroidal vasculature is essential for retinal function. The status of the choroid appears to be a crucial determinant in the pathogenesis of diseases such as age-related choroidal atrophy, myopic chorioretinal atrophy, central serous chorioretinopathy, chorioretinal inflammatory diseases, and tumors.

The in vivo structure of the choroid in health and disease is incompletely visualized with traditional imaging modalities, including indocyanine green angiography and ultrasonography.

Optical coherence tomography (OCT) is an established medical imaging technique that uses light to capture micrometer-resolution, three-dimensional images from within optical scattering media. OCT is based on low-coherence interferometry. Nowadays, it is essential for managing retinal conditions.

Unfortunately, standard spectral domain optic coherence tomography (SD-OCT) is of limited use in imaging choroidal morphology.

A modification to the standard technique, termed enhanced depth imaging optical coherence tomography (EDI-OCT), is able to image the choroid with better clarity using commercial SD-OCTs.

With the advent of enhanced depth imaging optical coherence tomography (EDI-OCT), detailed visualisation of the choroid in vivo has been made possible possible. Measurements of choroidal thickness (CT) have also enabled new directions in research to study normal and pathological processes within the choroid.

However, EDI-OCT has its own limitations: the outer choroidal border cannot always be visualized and choroidal details sometime lack clarity.

A new generation of OCTs has been made available, based on swept-source technology.

Swept source OCT (SS-OCT) has been shown to be more precise than spectral domain EDI-OCT in measuring choroidal thickness.

Our department is now using two OCTs, one is a SD- OCT (Canon HS-100), the other one a SS- OCT (Topcon DRI Atlantis).

The investigators would be interested in applying the EDI technique to SS- OCT, by modifying the acquisition protocol. Doing so, the investigators hope to improve the visualization of the choroid and perhaps even of the sclera.

This modification is based on the technique described by Spaide for SD-OCT.

From the patient's perspective, it only involves spending more time fixing the green stimulus (about 4 minutes instead of 2, in order to follow the swept-source EDI protocol in addition to standard swept source).

Conditions

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Retina, Choroid, Sclera

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Investigators

Intervention Type DEVICE

Fundus imaging

Interventions

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DRI-1 Swept source OCT, Atlantis, Topcon

Fundus imaging

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Ability to sit for OCT

Exclusion Criteria

* Media opacities precluding fundus view

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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185/14

Identifier Type: -

Identifier Source: org_study_id

Swept Source Enhanced Depth Imaging Optical Coherence Tomography

Study Results

Basic Information

Brief Summary

Detailed Description

Conditions

Study Design

Study Groups

control group

DRI-1 Swept source OCT, Atlantis, Topcon

mydramide only

DRI-1 Swept source OCT, Atlantis, Topcon

mydramide and ephrine 10%

DRI-1 Swept source OCT, Atlantis, Topcon

All patients presenting with RD

DRI-1 Swept source OCT, Atlantis, Topcon

Impact of previous grid treatment

DRI-1 Swept source OCT, Atlantis, Topcon

Effect of glaucoma medications

DRI-1 Swept source OCT, Atlantis, Topcon

Effect of arteritic/non-arteritic AION

DRI-1 Swept source OCT, Atlantis, Topcon

NVAMD poorly responsive to Rx

DRI-1 Swept source OCT, Atlantis, Topcon

Retrospective analysis

DRI-1 Swept source OCT, Atlantis, Topcon

Interventions

DRI-1 Swept source OCT, Atlantis, Topcon

Eligibility Criteria

Inclusion Criteria

Exclusion Criteria

Sponsors

Shaare Zedek Medical Center

Responsible Party

Other Identifiers

185/14