Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in COPD Cachexia

NCT ID: NCT02442908

Last Updated: 2020-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-05-31

Study Completion Date

2016-06-30

Brief Summary

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SF-K002 is a pilot study in patients with moderate to severe COPD suffering from involuntary weight loss. The study is 12 weeks, double-blinded, placebo controlled and the main objective is to study the safety and tolerability of Nutrifriend Cachexia.

Detailed Description

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This study is a 12-week, randomised, parallel group, placebo controlled, multi-centre study. The primary objective is to evaluate the safety and tolerability of Nutrifriend Cachexia in patients with COPD. The secondary objectives of the study are to evaluate effects on body composition, muscle function, daily activity, inflammation, lung function, compliance, appetite and Quality of Life.

Conditions

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COPD Cachexia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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NF Cachexia

Nutrifriend Cachexia, an Omega-3 enriched fruit juice (non complete dietary formula).

Group Type EXPERIMENTAL

Nutrifriend Cachexia

Intervention Type DIETARY_SUPPLEMENT

2 daily for 12 weeks

Placebo

An isocaloric placebo comparator

Group Type PLACEBO_COMPARATOR

Isocaloric placebo

Intervention Type DIETARY_SUPPLEMENT

2 daily for 12 weeks

Interventions

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Nutrifriend Cachexia

2 daily for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

Isocaloric placebo

2 daily for 12 weeks

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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NFCax Placobo

Eligibility Criteria

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Inclusion Criteria

* Age \>50 years
* Moderate to severe COPD patients with forced expiratory volume (FEV1) of 30-60%
* Involuntary weight loss \<10%
* 18 kg/m2 ≤ BMI ≤ 32 kg/m2

Exclusion Criteria

* Exacerbation of COPD within 3 months prior to screening
* Treatment with oral corticosteroids (\>5 mg/day) within 3 months prior to screening
* Treatment with anabolic steroids within 3 months prior to screening
* Current oxygen treatment or home ventilation therapy
* Change in smoking habits during the previous 6 months
* Major changes in COPD maintenance treatment within 3 months prior to screening
* Other cachectic disorders such as cancer, renal or hepatic disorders
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Smartfish AS

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ladulaas kliniska studier

Borås, , Sweden

Site Status

Pharmasite

Helsingborg, , Sweden

Site Status

Pharmasite

Malmo, , Sweden

Site Status

A+ Science City Site

Stockholm, , Sweden

Site Status

Countries

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Sweden

References

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Calder PC, Laviano A, Lonnqvist F, Muscaritoli M, Ohlander M, Schols A. Targeted medical nutrition for cachexia in chronic obstructive pulmonary disease: a randomized, controlled trial. J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):28-40. doi: 10.1002/jcsm.12228. Epub 2017 Sep 10.

Reference Type BACKGROUND
PMID: 28891198 (View on PubMed)

Related Links

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http://onlinelibrary.wiley.com/doi/10.1002/jcsm.12228/abstract;jsessionid=8E0C9717131FC3B85669192A0E4F08AB.f02t03

Targeted medical nutrition for cachexia in chronic obstructive pulmonary disease: a randomized, controlled trial

Other Identifiers

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SF-K002

Identifier Type: -

Identifier Source: org_study_id