Trial Outcomes & Findings for Fade Upon TOF Stimulation Induced by Succinylcholine (NCT NCT02425449)

Results Overview

We stimulated the ulnar nerve at the wrist four times (over 1.5 seconds) every 20 seconds. We measured the ratio of the fourth contraction to the first contraction before and after the administration of succinylcholine. Before administering succinylcholine the ratio is normally one. After the administration of succinylcholine the first contraction diminishes, but the fourth contraction diminishes even more. This results in a ratio of T4 to T1 being less than one. The lowest ratio recorded after the administration after the administration of succinylcholine is reported as our outcome measure.

Recruitment status

COMPLETED

Study phase

PHASE4

Target enrollment

19 participants

Primary outcome timeframe

for the duration of the effect of succinylcholine generally expected to be 6-10 minutes

Results posted on

2018-01-02

Participant Flow

Participant milestones

Participant milestones
Measure	Arm 2 0.15 mg/kg of succinycholine arm Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.	Arm 3 0.2 mg/kg of succinylcholne arm Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.	Arm 4 0.25 mg/kg succinylcholine arm Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.	Arm 5 0.3 mg/kg succinylcholine arm Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.
Overall Study STARTED	4	5	5	5
Overall Study COMPLETED	4	5	5	5
Overall Study NOT COMPLETED	0	0	0	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Fade Upon TOF Stimulation Induced by Succinylcholine

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Arm 1 0.1 mg/kg of succinylcholine arm Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.	Arm 2 n=4 Participants 0.15 mg/kg of succinycholine arm Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.	Arm 3 n=5 Participants 0.2 mg/kg of succinylcholne arm Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.	Arm 4 n=5 Participants 0.25 mg/kg succinylcholine arm Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.	Arm 5 n=5 Participants 0.3 mg/kg succinylcholine arm Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.	Total n=19 Participants Total of all reporting groups
Age, Continuous	—	35.3 years STANDARD_DEVIATION 6.7 • n=7 Participants	38.4 years STANDARD_DEVIATION 11.1 • n=5 Participants	37.4 years STANDARD_DEVIATION 6.2 • n=4 Participants	36.2 years STANDARD_DEVIATION 12.8 • n=21 Participants	36.9 years STANDARD_DEVIATION 8.4 • n=8 Participants
Sex: Female, Male Female	—	1 Participants n=7 Participants	3 Participants n=5 Participants	3 Participants n=4 Participants	4 Participants n=21 Participants	11 Participants n=8 Participants
Sex: Female, Male Male	—	3 Participants n=7 Participants	2 Participants n=5 Participants	2 Participants n=4 Participants	1 Participants n=21 Participants	8 Participants n=8 Participants

PRIMARY outcome

Timeframe: for the duration of the effect of succinylcholine generally expected to be 6-10 minutes

We stimulated the ulnar nerve at the wrist four times (over 1.5 seconds) every 20 seconds. We measured the ratio of the fourth contraction to the first contraction before and after the administration of succinylcholine. Before administering succinylcholine the ratio is normally one. After the administration of succinylcholine the first contraction diminishes, but the fourth contraction diminishes even more. This results in a ratio of T4 to T1 being less than one. The lowest ratio recorded after the administration after the administration of succinylcholine is reported as our outcome measure.