Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
50 participants
INTERVENTIONAL
2016-01-31
2018-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
QUADRUPLE
Study Groups
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Preemptive paracetamol
1000mg intravenous paracetamol given ≥15 minutes before surgical incision and intravenous saline 15 minutes before the end of surgery
Intravenous paracetamol
1000mg intravenous solution for infusion
Intravenous saline 0.9%
0.9% sodium chloride in order to ensure double-blinding
Postincision paracetamol
Intravenous saline ≥15 minutes before surgical incision and 1000mg intravenous paracetamol given 15 minutes before the end of surgery
Intravenous paracetamol
1000mg intravenous solution for infusion
Intravenous saline 0.9%
0.9% sodium chloride in order to ensure double-blinding
Interventions
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Intravenous paracetamol
1000mg intravenous solution for infusion
Intravenous saline 0.9%
0.9% sodium chloride in order to ensure double-blinding
Eligibility Criteria
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Inclusion Criteria
* Patients listed for non-malignant cervical spinal surgery
* General anaesthesia
* Capacity to give informed consent
* Ability to use PCA device and pain score scale
* ASA I, II and III
* \>50kg in weight
Exclusion Criteria
* Liver disease
* Renal disease (creatinine clearance \<30ml/min)
* Bleeding disorder
* Chronic alcoholism
* Chronic malnutrition
* Dehydration
* G6PD deficiency
* Hypernatraemia (Na \>150)
* Hypokalaemia (K \<3.5) and hyperchloraemia
* Pregnancy or breast-feeding
18 Years
80 Years
ALL
No
Sponsors
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University of Nottingham
OTHER
Responsible Party
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Principal Investigators
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John Williams
Role: PRINCIPAL_INVESTIGATOR
University of Nottiongham
Central Contacts
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Other Identifiers
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15029
Identifier Type: -
Identifier Source: org_study_id