Radotinib as 3rd or Later Line Therapy in CP-CML

NCT ID: NCT02422719

Last Updated: 2016-05-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

73 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-30

Study Completion Date

2019-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine whether radotinib is effective and safe for patients with chronic myeloid leukemia, chronic phase who are intolerable or resistant to prior 2 or more tyrosine kinase inhibitors.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The purpose of this study is to determine whether radotinib 400mg bid is effective and safe for patients with chronic myeloid leukemia, chronic phase who are intolerable or resistant to prior 2 or more tyrosine kinase inhibitors. The primary end point is major cytogenetic response by 12 months.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Chronic Myeloid Leukemia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Radotinib

Radotinib treatement single arm

Group Type EXPERIMENTAL

Radotinib

Intervention Type DRUG

Radotinib 400mg bid

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Radotinib

Radotinib 400mg bid

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Supect

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Chronic myeloid leukemia chronic phase (CP-CML) patients who are not tolerable or resistant to prior 2 or more tyrosine kinase inhibitors (TKIs).
* ECOG 0, 1, 2
* Patients who are agree and signed to informed consent.

Exclusion Criteria

* T315I mutation
* Prior exposure to radotinib
* Accelerated or blastic phase
* galactose intolerance, severe lactase deficiency or glucose galactose malabsorption
* Prior history of intensive cytotoxic chemotherapy except for TKIs
* Significant cardiac problem
* QTcF \> 450 msec
* Pancreatitis history prior to study enrollment
* Clinically significant malignant disease other than CML
* Pregnant or breast feeding woman
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Ulsan University Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Hawk Kim

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Hawk Kim, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Ulsan University Hospital

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Ulsan University Hospital

Ulsan, , South Korea

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

South Korea

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Hae Kyung Shin, R.N.

Role: CONTACT

+82-52-230-1418

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Hawk Kim, M.D., Ph.D.

Role: primary

+82-52-250-8892

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

RAD-201501

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

KRT-232 and TKI Study in Chronic Myeloid Leukemia
NCT04835584 RECRUITING PHASE1/PHASE2