The Association Between Psoriasis and Intestinal Bacterial Population
NCT ID: NCT02417792
Last Updated: 2019-09-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
46 participants
OBSERVATIONAL
2015-05-14
2019-02-18
Brief Summary
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Detailed Description
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Psoriasis is an immune related dermal disease. The trigger for this disease is currently unknown but, it is possible that intestinal bacteria are a factor in its development.
Study design:
Participants will be divided into 3 groups:
* Psoriasis patients treated with topical medications
* Psoriasis patients treated with IV or sub-cutaneous medications (e.g biological medications)
* Healthy participants (control group) Bacterial genomic DNA will be extracted from stool samples of participants. The intestinal bacterial populations will be compared in order to examine whether there are differences between the groups.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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control
group of healthy participants
No interventions assigned to this group
Topical psoriasis treatment
Group of patients who are treated with topical medications for psoriasis
No interventions assigned to this group
Systemic psoriasis treatment
Group of patients who are treated with systematic medications for psoriasis
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* incapable of signing an inform concent.
18 Years
80 Years
ALL
Yes
Sponsors
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Tel Aviv Medical Center
OTHER
Assuta Hospital Systems
OTHER
Responsible Party
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Principal Investigators
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Jonathan Shapiro, Dr.
Role: PRINCIPAL_INVESTIGATOR
Maccabi Healthcare Services, Israel
References
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Shaw SY, Blanchard JF, Bernstein CN. Association between early childhood otitis media and pediatric inflammatory bowel disease: an exploratory population-based analysis. J Pediatr. 2013 Mar;162(3):510-4. doi: 10.1016/j.jpeds.2012.08.037. Epub 2012 Oct 17.
Shaw SY, Blanchard JF, Bernstein CN. Association between the use of antibiotics in the first year of life and pediatric inflammatory bowel disease. Am J Gastroenterol. 2010 Dec;105(12):2687-92. doi: 10.1038/ajg.2010.398. Epub 2010 Oct 12.
Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Pena AG, Goodrich JK, Gordon JI, Huttley GA, Kelley ST, Knights D, Koenig JE, Ley RE, Lozupone CA, McDonald D, Muegge BD, Pirrung M, Reeder J, Sevinsky JR, Turnbaugh PJ, Walters WA, Widmann J, Yatsunenko T, Zaneveld J, Knight R. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010 May;7(5):335-6. doi: 10.1038/nmeth.f.303. Epub 2010 Apr 11. No abstract available.
Edgar RC. Search and clustering orders of magnitude faster than BLAST. Bioinformatics. 2010 Oct 1;26(19):2460-1. doi: 10.1093/bioinformatics/btq461. Epub 2010 Aug 12.
Henseler T, Christophers E. Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol. 1985 Sep;13(3):450-6. doi: 10.1016/s0190-9622(85)70188-0.
Other Identifiers
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2
Identifier Type: -
Identifier Source: org_study_id
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