Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging Technologies

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-08-31

Study Completion Date

2016-12-31

Brief Summary

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The researchers will assess the effects of treatment with tretinoin cream on human skin by using non-invasive optical imaging technologies.

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Detailed Description

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The researchers will evaluate changes in the dermis and skin properties as the effect of treatment with Tretinoin cream (0.1%) by using the following optical imaging techniques.

1. Multiphoton microscopy using a clinical tomograph (MPTflex, Jenlab, Germany)
2. Multispectral Imaging using a device developed at Beckman Laser Institute, UC Irvine

Conditions

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Collagen Fibril Alteration

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Tretinoin cream 0.1%

Assessment of the skin change

Group Type EXPERIMENTAL

Tretinoin cream 0.1%

Intervention Type DRUG

Assessment of the skin change

Interventions

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Tretinoin cream 0.1%

Assessment of the skin change

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Female 45 years of age or older - Skin type scale I to III

Exclusion Criteria

* Large amount of dark, coarse hair on the arms
* History of allergies to alpha hydroxy acids (AHAs), retinoids, soaps, fragrances, sunscreens or Latex
* Currently using over-the-counter AHA or retinol within one month or prescription retinoid within three months of the start of the study.
* History of skin cancer, including squamous or basal cell carcinoma at the treatment site or history of malignant melanoma.
* History of diabetes
* Currently pregnant or nursing

Minimum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes