Effect of Immersion, Performed Under the Conditions of Obstetrical Dilatation Bath, on Diuresis and Hemodynamic Variables in Young Women

NCT ID: NCT02409953

Last Updated: 2017-10-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-15

Study Completion Date

2016-05-13

Brief Summary

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Like in the full immersion, studied in the context of diving, immersion in water causes a cascade of events with hemodynamic and hormonal consequences.

First, immersion leads to a relative hypervolemia by venous redistribution and then 40-60 minutes later, hypovolemia by stimulating diuresis.

Dilatation bath is helpful in relieving moderate pain the first stage of obstetrical labor.

However, when the labor progresses, the dilatation bath is no longer sufficient and epidural analgesia remains the only effective method to control pain.

Used before the realization of an epidural analgesia, dilatation bath could affect blood volume and thus worsen the hemodynamic consequences of the sympathetic block that is linked to the installation of sensory block of the epidural analgesia in the parturient (severe prolonged maternal hypotension that can cause a decrease of the placental perfusion and fetal distress).

Before beginning a study in pregnant women, it seems essential to study the hemodynamic consequences of the dilatation bath in a comparable population of volunteers healthy young women and out of the obstetrical context.

Detailed Description

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Conditions

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Healthy

Keywords

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volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Bath

Group Type EXPERIMENTAL

Lying in a bath during 2 hours

Intervention Type OTHER

Bed

Group Type PLACEBO_COMPARATOR

Lying in a bed during 2 hours

Intervention Type OTHER

Interventions

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Lying in a bath during 2 hours

Intervention Type OTHER

Lying in a bed during 2 hours

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Healthy female volunteers aged 18 to 45 years

Exclusion Criteria

* pregnancy
* menopause (confirmed for at least 12 weeks)
* breastfeeding
* Proteinuria\> 2 cross on the dipstick
* Glycosuria \> 2 cross on the dipstick
* subject with no empty stomach for at least 8 hours
* Taking medication in the week before the test affecting diuresis, production of antidiuretic hormone or on the cardiovascular system: paracetamol, nonsteroidal anti-inflammatory Alcohol intake the day before the tes
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Service d'Anesthésie - Réanimation Chirurgicale de Hautepierre

Strasbourg, Alsace, France

Site Status

Countries

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France

Other Identifiers

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5979

Identifier Type: -

Identifier Source: org_study_id