Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment

NCT ID: NCT02408445

Last Updated: 2020-04-15

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-05-08

Study Completion Date

2020-01-01

Brief Summary

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This research study in infant males with Klinefelter syndrome (47,XXY) will learn more about body composition (muscle and fat) and male hormones and look at the effect of testosterone shots on body composition. The Investigators know that older boys and men with Klinefelter syndrome often have more fat compared to muscle than adults without Klinefelter syndrome, but we do not know if this difference is present at birth or develops over time. The Investigators will learn if body composition and motor skills are improved with testosterone treatment in infants with Klinefelter syndrome.

Detailed Description

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Conditions

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Klinefelter Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Testosterone treatment

Testosterone cypionate (200 mg/ml) intramuscular injection

Group Type EXPERIMENTAL

testosterone cypionate 200mg/ml

Intervention Type DRUG

Subjects in this group will be randomized to receive testosterone cypionate 200 mg/ml to be given intramuscularly every 4 weeks for a total of 3 doses.

No treatment

Subjects will not receive any testosterone during the study period.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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testosterone cypionate 200mg/ml

Subjects in this group will be randomized to receive testosterone cypionate 200 mg/ml to be given intramuscularly every 4 weeks for a total of 3 doses.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Male infants with 47,XXY karyotype

Exclusion Criteria

* Gestational age at birth \<36 weeks
* Birth weight \<5%ile or \>95% for gestational age
* History of thrombosis in a first degree relative
* Exposure to androgen therapy outside of the study protocol.
Minimum Eligible Age

42 Days

Maximum Eligible Age

108 Days

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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University of Colorado, Denver

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Shanlee M Davis, MD

Role: PRINCIPAL_INVESTIGATOR

University of Colorado, Denver

Locations

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Children's Hospital Colorado

Aurora, Colorado, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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UL1TR001082

Identifier Type: NIH

Identifier Source: secondary_id

View Link

14-1720

Identifier Type: -

Identifier Source: org_study_id

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