Collaborative Care for the Detection and Management of Depression Among Adults Receiving Antiretroviral Therapy in South Africa
NCT ID: NCT02407691
Last Updated: 2023-11-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
2002 participants
INTERVENTIONAL
2015-04-30
2018-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
HEALTH_SERVICES_RESEARCH
SINGLE
Study Groups
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Primary Care 101 Enhanced guideline
Primary Care 101 guideline with enhanced mental health
Primary care 101 plus mental health
A facility-based stepped care intervention combining depression case detection by non-physician clinicians with group counselling intervention delivered by lay-health workers.
Standard of care
Primary Care 101 standard version guideline
Standard Primary Care 101
Standard Primary Care 101 guideline with standard training
Interventions
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Primary care 101 plus mental health
A facility-based stepped care intervention combining depression case detection by non-physician clinicians with group counselling intervention delivered by lay-health workers.
Standard Primary Care 101
Standard Primary Care 101 guideline with standard training
Eligibility Criteria
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Inclusion Criteria
1\) 40 nurse-led primary care clinics providing ART in the Dr Kenneth Kaunda and Bojonala districts of the North West Province, South Africa
Patients:
1. Age ≥ 18 years and
2. Receiving ART at the time of enrollment and
3. Depressive symptoms, as indicated by a total score of 9 or more on the PHQ-9 and
4. Planning to reside in the area for the next year and
5. Capable of actively engaging in an interviewer-administered questionnaire at the time of recruitment, six and twelve months later and
6. Written consent to participate in the study
Exclusion Criteria
1\) Clinics which participate in the formative research and piloting of the intervention
Patients:
18 Years
ALL
No
Sponsors
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King's College London
OTHER
University of KwaZulu
OTHER
University of Cape Town
OTHER
Responsible Party
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Babalwa Zani
www.knowledgetranslation.co.za
Principal Investigators
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Lara Fairall, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Cape Town, Cape Town, South Africa
Inge Pitersen, PhD
Role: PRINCIPAL_INVESTIGATOR
University of KwaZulu-Natal, Durban, South Africa
Graham Thornicroft, PhD
Role: PRINCIPAL_INVESTIGATOR
King's College London
Locations
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Dr Kenneth Kaunda District
Klerksdorp, North West, South Africa
Bojanala District
Rustenburg, North West, South Africa
Countries
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References
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Zani B, Fairall L, Petersen I, Folb N, Bhana A, Thornicroft G, Hanass-Hancock J, Selohilwe O, Petrus R, Carmona S, Lombard C, Lund C, Levitt N, Bachmann M. Sociodemographic and health-related factors associated with viral load non-suppression and body mass index in adults with depression symptoms receiving antiretroviral therapy in South African primary care: secondary analysis of randomised trial data. medRxiv [Preprint]. 2025 Aug 5:2025.08.01.25332690. doi: 10.1101/2025.08.01.25332690.
Zani B, Fairall L, Petersen I, Folb N, Bhana A, Hanass-Hancock J, Selohilwe O, Petrus R, Georgeu-Pepper D, Mntambo N, Kathree T, Carmona S, Lombard C, Lund C, Levitt N, Bachmann M, Thornicroft G. Effectiveness of a task-sharing collaborative care model for the detection and management of depression among adults receiving antiretroviral therapy in primary care facilities in South Africa: A pragmatic cluster randomised controlled trial. J Affect Disord. 2025 Feb 1;370:499-510. doi: 10.1016/j.jad.2024.10.061. Epub 2024 Oct 21.
Fairall L, Petersen I, Zani B, Folb N, Georgeu-Pepper D, Selohilwe O, Petrus R, Mntambo N, Bhana A, Lombard C, Bachmann M, Lund C, Hanass-Hancock J, Chisholm D, McCrone P, Carmona S, Gaziano T, Levitt N, Kathree T, Thornicroft G; CobALT research team. Collaborative care for the detection and management of depression among adults receiving antiretroviral therapy in South Africa: study protocol for the CobALT randomised controlled trial. Trials. 2018 Mar 22;19(1):193. doi: 10.1186/s13063-018-2517-7.
Related Links
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Related Info
Other Identifiers
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