Gonadotropin-releasing Hormone (GnRH) Downregulation Versus Oral Anticonception Prior to ART in Postoperative Endometriosis Patients
NCT ID: NCT02400801
Last Updated: 2024-07-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
166 participants
INTERVENTIONAL
2013-06-30
2018-01-26
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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oral oestroprogestogen pre-treatment
preparation with oral oestroprogestogens prior to downregulation in an assisted reproductive technology treatment (ART) cycle
ethinylestradiol + dienogest
oral oestroprogestogen
gonadotropin-releasing hormone (GnRH) pre-treatment
preparation with gonadotropin-releasing hormone (GnRH) analogues prior to downregulation in an assisted reproductive technology treatment (ART) cycle
triptorelin
gonadotropin-releasing hormone (GnRH) agonist
Interventions
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triptorelin
gonadotropin-releasing hormone (GnRH) agonist
ethinylestradiol + dienogest
oral oestroprogestogen
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* only first three ART cycles
* normal uterine cavity
* Eligible for ovarian stimulation with long agonist protocol
Exclusion Criteria
* presence of large intramural fibroids (\> 3 cm)
* \<4 oocytes obtained in any previous fresh ART cycle
* ART with sperm derived from testicular biopsy
* ART with Preimplantation Genetic Diagnosis/Screening
18 Years
39 Years
FEMALE
No
Sponsors
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Universitaire Ziekenhuizen KU Leuven
OTHER
Responsible Party
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Principal Investigators
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Thomas M D'Hooghe, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
UZ Leuven
Locations
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UZ Leuven
Leuven, , Belgium
Countries
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References
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Tomassetti C, Beukeleirs T, Conforti A, Debrock S, Peeraer K, Meuleman C, D'Hooghe T. The ultra-long study: a randomized controlled trial evaluating long-term GnRH downregulation prior to ART in women with endometriosis. Hum Reprod. 2021 Sep 18;36(10):2676-2686. doi: 10.1093/humrep/deab163.
Other Identifiers
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S55300
Identifier Type: -
Identifier Source: org_study_id
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