Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications
NCT ID: NCT02399878
Last Updated: 2016-03-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
70000 participants
OBSERVATIONAL
2007-01-31
Brief Summary
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It has been shown that intra-operative protective ventilation is associated with a reduced risk of respiratory complications. The effects of intra-operative inspiratory oxygen fraction (FiO2) remain to be investigated.
In this study, the investigators aim to investigate the association between intra-operative FiO2 and respiratory complication as well as surgical site infection and ICU admission in patients undergoing non-cardiothoracic surgery. The investigators primary hypothesis is that high intra-operative FiO2 increases the risk of postoperative respiratory complications independent of predefined risk factors.
Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients undergoing surgery
All non-cardiothoracic surgical patients aged 18 years or above receiving general anesthesia at Massachusetts General Hospital between January 2007 and August 2014.
Inspiratory oxygen
Interventions
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Inspiratory oxygen
Eligibility Criteria
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Inclusion Criteria
* Tracheally intubated at the beginning of the procedure and extubated at the end of the procedure
* above18 years of age
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Herlev Hospital
OTHER
Rigshospitalet, Denmark
OTHER
Massachusetts General Hospital
OTHER
Responsible Party
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Matthias Eikermann
MD, PhD, Associate Professor
Principal Investigators
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Matthias Eikermann, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
MGH
References
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Staehr-Rye AK, Meyhoff CS, Scheffenbichler FT, Vidal Melo MF, Gatke MR, Walsh JL, Ladha KS, Grabitz SD, Nikolov MI, Kurth T, Rasmussen LS, Eikermann M. High intraoperative inspiratory oxygen fraction and risk of major respiratory complications. Br J Anaesth. 2017 Jul 1;119(1):140-149. doi: 10.1093/bja/aex128.
Other Identifiers
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03-2015
Identifier Type: -
Identifier Source: org_study_id