Pharmacokinetic Properties of Vortioxetine in Healthy Young Chinese Men and Women

NCT ID: NCT02386488

Last Updated: 2015-05-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

64 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-31

Study Completion Date

2015-05-31

Brief Summary

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The purpose of this study is to determine the pharmacokinetic (PK) parameters of vortioxetine after single and multiple oral dosing to healthy Chinese men and women.

Detailed Description

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Conditions

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Pharmacokinetics

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Vortioxetine 10 mg single dose

8 men and 8 women

Group Type EXPERIMENTAL

Vortioxetine 10 mg single dose

Intervention Type DRUG

10 mg tablet for oral use, single dose

Vortioxetine 20 mg single dose

8 men and 8 women

Group Type EXPERIMENTAL

Vortioxetine 20 mg single dose

Intervention Type DRUG

Two 10 mg tablets for oral use, single dose,

Vortioxetine 10 mg multiple dose

8 men and 8 women

Group Type EXPERIMENTAL

Vortioxetine 10 mg multiple dose

Intervention Type DRUG

10 mg tablet for oral use once, daily for 14 days.

Vortioxetine 20 mg multiple dose

8 men and 8 women

Group Type EXPERIMENTAL

Vortioxetine 20 mg multiple dose

Intervention Type DRUG

Two 10 mg tablets for oral use, once daily for 14 days.

Interventions

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Vortioxetine 10 mg single dose

10 mg tablet for oral use, single dose

Intervention Type DRUG

Vortioxetine 20 mg single dose

Two 10 mg tablets for oral use, single dose,

Intervention Type DRUG

Vortioxetine 10 mg multiple dose

10 mg tablet for oral use once, daily for 14 days.

Intervention Type DRUG

Vortioxetine 20 mg multiple dose

Two 10 mg tablets for oral use, once daily for 14 days.

Intervention Type DRUG

Other Intervention Names

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Lu AA21004 Lu AA21004 Lu AA21004 Lu AA21004

Eligibility Criteria

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Inclusion Criteria

* Healthy young Chinese men or women
* Between 18 and 45 years of age (extremes included)
* BMI between 18.5 and 24 kg/m2 (extremes included)
* Body weight ≥45 kg.

Exclusion Criteria

* Pregnant or lactating.
* Previously been dosed with vortioxetine
* The subject has taken any investigational medicinal products within 3 months prior to the first dose of IMP (investigational medicinal product)
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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H. Lundbeck A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Email contact via H. Lundbeck A/S

Role: STUDY_DIRECTOR

[email protected]

Locations

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CB801

Chengdu, , China

Site Status

Countries

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China

Other Identifiers

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16060A

Identifier Type: -

Identifier Source: org_study_id

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