Air Barrier System for the Prevention of Prosthesis-related Infections

NCT ID: NCT02376153

Last Updated: 2018-09-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

816 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-24

Study Completion Date

2019-10-31

Brief Summary

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This is a prospective, randomized, blinded clinical trial to determine if the Air Barrier System device reduces the incidence of surgical site infection after total hip replacement, acetabular repair, posterior spinal fusion, and prosthetic vascular graft procedures.

Detailed Description

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This project is an evaluation of a novel device, the Air Barrier System (ABS), to reduce the risk of prosthesis-related surgical site infection in a multi-center clinical trial. The ABS shields surgical incisions intra-operatively by creating a field of high-purity air surrounding an incision that prevents airborne microorganisms from entering the incision.

This research will evaluate ABS performance in a prospective, randomized, blinded multi-center trial. The surgical procedures studied will include total hip arthroplasty, trauma-related acetabula reconstruction, posterior instrumented spine fusion, and prosthetic vascular graft procedures. Patients will be enrolled during the first two years of the study, and CDC guidelines require a one year follow-up period to monitor patients for potential prosthesis-related infections.

Conditions

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Prosthesis-Related Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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ABS deployed and active

Air Barrier System (ABS) will be deployed onto the surgical field and activated.

Group Type EXPERIMENTAL

ABS deployed and active

Intervention Type DEVICE

ABS is deployed onto surgical field and is turned on.

ABS deployed and NOT active

Air Barrier System (ABS) will be deployed onto the surgical field and NOT activated. This is a sham comparator to reduce the influence of the presence of the device and provide user blinding.

Group Type SHAM_COMPARATOR

ABS deployed and NOT active

Intervention Type DEVICE

ABS is deployed onto surgical field and is NOT turned on.

Interventions

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ABS deployed and active

ABS is deployed onto surgical field and is turned on.

Intervention Type DEVICE

ABS deployed and NOT active

ABS is deployed onto surgical field and is NOT turned on.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Total hip arthroplasty;
* Acetabular repair with instrumentation;
* Posterior lumbar, cervical, or thoracic (up to and including 6 vertebral levels) spine fusion with instrumentation and vascular prosthetic graft implantation.

Exclusion Criteria

* History of prior prosthesis infection;
* Active infection;
* Open traumatic wounds as is the case after some acetabular fractures.
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nimbic Systems, LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Sean Self

Role: PRINCIPAL_INVESTIGATOR

Investigator

Locations

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Michael E. DeBakey VA Medical Center

Houston, Texas, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Sean Self

Role: CONTACT

281-565-5715

Kylie Pflieger

Role: CONTACT

281-565-5701

Facility Contacts

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Colleen C Stewart, MSN

Role: primary

713-794-7127

Other Identifiers

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ABS004-H-35894

Identifier Type: -

Identifier Source: org_study_id

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