Trial Outcomes & Findings for Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2 (NCT NCT02371759)
NCT ID: NCT02371759
Last Updated: 2017-05-03
Results Overview
Time until cessation in soft tissue numbness
Recruitment status
COMPLETED
Study phase
PHASE3
Target enrollment
256 participants
Primary outcome timeframe
Up to 6 hours after local anesthesia injection
Results posted on
2017-05-03
Participant Flow
Participants recruited between june 2013 and december 2015 among the patients of Clinic of Oral Surgery, Faculty of Dental Medicine, University of Belgrade
Participant milestones
| Measure |
Diabetics: L+C Maxillary Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Overall Study
STARTED
|
32
|
31
|
33
|
31
|
27
|
26
|
25
|
28
|
|
Overall Study
COMPLETED
|
29
|
30
|
32
|
31
|
24
|
25
|
25
|
24
|
|
Overall Study
NOT COMPLETED
|
3
|
1
|
1
|
0
|
3
|
1
|
0
|
4
|
Reasons for withdrawal
| Measure |
Diabetics: L+C Maxillary Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Overall Study
Protocol Violation
|
3
|
1
|
1
|
0
|
3
|
1
|
0
|
3
|
|
Overall Study
Withdrawal by Subject
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
Baseline Characteristics
Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2
Baseline characteristics by cohort
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Total
n=220 Participants
Total of all reporting groups
|
|---|---|---|---|---|---|---|---|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=21 Participants
|
0 Participants
n=10 Participants
|
0 Participants
n=115 Participants
|
0 Participants
n=6 Participants
|
0 Participants
n=6 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
29 Participants
n=5 Participants
|
30 Participants
n=7 Participants
|
32 Participants
n=5 Participants
|
31 Participants
n=4 Participants
|
24 Participants
n=21 Participants
|
25 Participants
n=10 Participants
|
25 Participants
n=115 Participants
|
24 Participants
n=6 Participants
|
220 Participants
n=6 Participants
|
|
Age, Categorical
>=65 years
|
0 Participants
n=5 Participants
|
0 Participants
n=7 Participants
|
0 Participants
n=5 Participants
|
0 Participants
n=4 Participants
|
0 Participants
n=21 Participants
|
0 Participants
n=10 Participants
|
0 Participants
n=115 Participants
|
0 Participants
n=6 Participants
|
0 Participants
n=6 Participants
|
|
Sex: Female, Male
Female
|
22 Participants
n=5 Participants
|
16 Participants
n=7 Participants
|
21 Participants
n=5 Participants
|
14 Participants
n=4 Participants
|
9 Participants
n=21 Participants
|
15 Participants
n=10 Participants
|
15 Participants
n=115 Participants
|
14 Participants
n=6 Participants
|
126 Participants
n=6 Participants
|
|
Sex: Female, Male
Male
|
7 Participants
n=5 Participants
|
14 Participants
n=7 Participants
|
11 Participants
n=5 Participants
|
17 Participants
n=4 Participants
|
15 Participants
n=21 Participants
|
10 Participants
n=10 Participants
|
10 Participants
n=115 Participants
|
10 Participants
n=6 Participants
|
94 Participants
n=6 Participants
|
|
Region of Enrollment
Serbia
|
32 participants
n=5 Participants
|
31 participants
n=7 Participants
|
33 participants
n=5 Participants
|
31 participants
n=4 Participants
|
24 participants
n=21 Participants
|
25 participants
n=10 Participants
|
25 participants
n=115 Participants
|
24 participants
n=6 Participants
|
220 participants
n=6 Participants
|
|
Body Mass
|
78.72 kilograms
STANDARD_DEVIATION 11.19 • n=5 Participants
|
75.03 kilograms
STANDARD_DEVIATION 11.53 • n=7 Participants
|
85.84 kilograms
STANDARD_DEVIATION 14.76 • n=5 Participants
|
79.45 kilograms
STANDARD_DEVIATION 17.34 • n=4 Participants
|
79.50 kilograms
STANDARD_DEVIATION 15.22 • n=21 Participants
|
74.59 kilograms
STANDARD_DEVIATION 9.64 • n=10 Participants
|
71.01 kilograms
STANDARD_DEVIATION 12.08 • n=115 Participants
|
71.59 kilograms
STANDARD_DEVIATION 7.81 • n=6 Participants
|
76.90 kilograms
STANDARD_DEVIATION 8.42 • n=6 Participants
|
|
Fasting Plasma Glucose
|
8.12 milimoles per liter
STANDARD_DEVIATION 3.01 • n=5 Participants
|
7.55 milimoles per liter
STANDARD_DEVIATION 2.53 • n=7 Participants
|
9.66 milimoles per liter
STANDARD_DEVIATION 4.02 • n=5 Participants
|
8.35 milimoles per liter
STANDARD_DEVIATION 2.49 • n=4 Participants
|
NA milimoles per liter
STANDARD_DEVIATION NA • n=21 Participants
|
NA milimoles per liter
STANDARD_DEVIATION NA • n=10 Participants
|
NA milimoles per liter
STANDARD_DEVIATION NA • n=115 Participants
|
NA milimoles per liter
STANDARD_DEVIATION NA • n=6 Participants
|
NA milimoles per liter
STANDARD_DEVIATION NA • n=6 Participants
|
|
Duration of Diabetes
|
6.83 years
STANDARD_DEVIATION 4.59 • n=5 Participants
|
9.57 years
STANDARD_DEVIATION 5.51 • n=7 Participants
|
9.77 years
STANDARD_DEVIATION 7.62 • n=5 Participants
|
9.27 years
STANDARD_DEVIATION 6.09 • n=4 Participants
|
NA years
STANDARD_DEVIATION NA • n=21 Participants
|
NA years
STANDARD_DEVIATION NA • n=10 Participants
|
NA years
STANDARD_DEVIATION NA • n=115 Participants
|
NA years
STANDARD_DEVIATION NA • n=6 Participants
|
NA years
STANDARD_DEVIATION NA • n=6 Participants
|
|
Glycosilated Hemoglobin
|
7.42 percents
STANDARD_DEVIATION 1.25 • n=5 Participants
|
7.55 percents
STANDARD_DEVIATION 2.53 • n=7 Participants
|
7.63 percents
STANDARD_DEVIATION 1.72 • n=5 Participants
|
7.97 percents
STANDARD_DEVIATION 1.50 • n=4 Participants
|
NA percents
STANDARD_DEVIATION NA • n=21 Participants
|
NA percents
STANDARD_DEVIATION NA • n=10 Participants
|
NA percents
STANDARD_DEVIATION NA • n=115 Participants
|
NA percents
STANDARD_DEVIATION NA • n=6 Participants
|
NA percents
STANDARD_DEVIATION NA • n=6 Participants
|
|
Number of participants with modified diet
|
22 Participants
n=5 Participants
|
30 Participants
n=7 Participants
|
31 Participants
n=5 Participants
|
30 Participants
n=4 Participants
|
NA Participants
n=21 Participants
|
NA Participants
n=10 Participants
|
NA Participants
n=115 Participants
|
NA Participants
n=6 Participants
|
NA Participants
n=6 Participants
|
|
Number of participants on OHA therapy
|
28 Participants
n=5 Participants
|
29 Participants
n=7 Participants
|
30 Participants
n=5 Participants
|
30 Participants
n=4 Participants
|
NA Participants
n=21 Participants
|
NA Participants
n=10 Participants
|
NA Participants
n=115 Participants
|
NA Participants
n=6 Participants
|
NA Participants
n=6 Participants
|
|
Number of participants on insulin therapy
|
2 Participants
n=5 Participants
|
4 Participants
n=7 Participants
|
8 Participants
n=5 Participants
|
4 Participants
n=4 Participants
|
NA Participants
n=21 Participants
|
NA Participants
n=10 Participants
|
NA Participants
n=115 Participants
|
NA Participants
n=6 Participants
|
NA Participants
n=6 Participants
|
|
Hypertension
|
16 Participants
n=5 Participants
|
26 Participants
n=7 Participants
|
19 Participants
n=5 Participants
|
17 Participants
n=4 Participants
|
NA Participants
n=21 Participants
|
NA Participants
n=10 Participants
|
NA Participants
n=115 Participants
|
NA Participants
n=6 Participants
|
NA Participants
n=6 Participants
|
|
Coronary Artery Disease
|
12 Participants
n=5 Participants
|
14 Participants
n=7 Participants
|
14 Participants
n=5 Participants
|
13 Participants
n=4 Participants
|
NA Participants
n=21 Participants
|
NA Participants
n=10 Participants
|
NA Participants
n=115 Participants
|
NA Participants
n=6 Participants
|
NA Participants
n=6 Participants
|
|
Peripheral Neuropathy
|
9 Participants
n=5 Participants
|
12 Participants
n=7 Participants
|
12 Participants
n=5 Participants
|
10 Participants
n=4 Participants
|
NA Participants
n=21 Participants
|
NA Participants
n=10 Participants
|
NA Participants
n=115 Participants
|
NA Participants
n=6 Participants
|
NA Participants
n=6 Participants
|
|
Intraoral Neuropathy
|
14 Participants
n=5 Participants
|
16 Participants
n=7 Participants
|
17 Participants
n=5 Participants
|
18 Participants
n=4 Participants
|
NA Participants
n=21 Participants
|
NA Participants
n=10 Participants
|
NA Participants
n=115 Participants
|
NA Participants
n=6 Participants
|
NA Participants
n=6 Participants
|
PRIMARY outcome
Timeframe: Up to 6 hours after local anesthesia injectionTime until cessation in soft tissue numbness
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Duration of Intraoral Local Anesthesia
|
132.48 minutes
Standard Deviation 91.86
|
173.27 minutes
Standard Deviation 70.44
|
182.09 minutes
Standard Deviation 57.86
|
195.35 minutes
Standard Deviation 68.99
|
108.82 minutes
Standard Deviation 27.76
|
155.59 minutes
Standard Deviation 60.75
|
114.74 minutes
Standard Deviation 39.72
|
172.91 minutes
Standard Deviation 68.93
|
PRIMARY outcome
Timeframe: Up to 10 minutes after local anesthesia injectionNumber of participants who reported values \> 0 after pin-prick testing, using Visual Analogue Scale (VAS) and Numerical Rating Scale (NRS). VAS is represented by line 100 mm long, with one end marked with 0 and words "no pain" , while the other end is marked with 100 and words "the worst pain imanginable". VRS scale is represented by line 100 mm long, marked with numbers from 0 to 10, where 0 corresponds to "no pain", and 10 corresponds to "the worst pain imaginable". For both scales, higher scores represent worse outcomes.
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Intensity of Intraoral Local Anesthesia
|
2 Participants
|
2 Participants
|
1 Participants
|
8 Participants
|
2 Participants
|
1 Participants
|
4 Participants
|
6 Participants
|
PRIMARY outcome
Timeframe: Baseline, 0 minutesOutcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Baseline Systolic Blood Pressure
|
135.2759 milimeters of Hg
Standard Deviation 16.69665611
|
137.7333 milimeters of Hg
Standard Deviation 18.43335308
|
134.8125 milimeters of Hg
Standard Deviation 18.66934265
|
134.4667 milimeters of Hg
Standard Deviation 17.69119729
|
124.0455 milimeters of Hg
Standard Deviation 11.07325079
|
128.1818 milimeters of Hg
Standard Deviation 15.49388931
|
125 milimeters of Hg
Standard Deviation 11.11918898
|
126.5909 milimeters of Hg
Standard Deviation 18.82322642
|
PRIMARY outcome
Timeframe: 10th minuteSystolic blood pressure values 5 minutes after local anesthesia injection
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Systolic Blood Pressure at 10 Minutes
|
130.3793 milimeters of Hg
Standard Deviation 18.81377496
|
136.8333 milimeters of Hg
Standard Deviation 14.27098173
|
137.4375 milimeters of Hg
Standard Deviation 19.73033934
|
132.6 milimeters of Hg
Standard Deviation 20.45858857
|
120.8182 milimeters of Hg
Standard Deviation 13.58092627
|
122.5909 milimeters of Hg
Standard Deviation 14.59503859
|
125.8261 milimeters of Hg
Standard Deviation 13.75979708
|
125,4091 milimeters of Hg
Standard Deviation 12.71541656
|
PRIMARY outcome
Timeframe: 15th minuteSystolic blood pressure values 10 minutes after local anesthesia injection
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Systolic Blood Pressure at 15 Minutes
|
133.5862 milimeters of Hg
Standard Deviation 13.51590925
|
133.4667 milimeters of Hg
Standard Deviation 14.12684735
|
137.4688 milimeters of Hg
Standard Deviation 19.28058421
|
132.0667 milimeters of Hg
Standard Deviation 17.89580957
|
114.4545 milimeters of Hg
Standard Deviation 11.89128241
|
116.9091 milimeters of Hg
Standard Deviation 12.78730431
|
123.8696 milimeters of Hg
Standard Deviation 13.61250878
|
127.1818 milimeters of Hg
Standard Deviation 18.58733917
|
PRIMARY outcome
Timeframe: 20th minuteSystolic blood pressure values 15 minutes after local anesthesia injection
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Systolic Blood Pressure at 20 Minutes
|
130.2414 milimeters of Hg
Standard Deviation 14.98011819
|
131.3333 milimeters of Hg
Standard Deviation 14.73755076
|
132.4063 milimeters of Hg
Standard Deviation 17.69428443
|
133.2333 milimeters of Hg
Standard Deviation 18.46560212
|
108.8182 milimeters of Hg
Standard Deviation 9.529630256
|
120.8636 milimeters of Hg
Standard Deviation 12.995587
|
123.8696 milimeters of Hg
Standard Deviation 12.15918788
|
124.6818 milimeters of Hg
Standard Deviation 19.56767588
|
PRIMARY outcome
Timeframe: 35th minuteSystolic blood pressure values 30 minutes after local anesthesia injection
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Systolic Blood Pressure at 35 Minutes
|
127.2759 milimeters of Hg
Standard Deviation 12.91979807
|
130.3 milimeters of Hg
Standard Deviation 13.12841089
|
132.5625 milimeters of Hg
Standard Deviation 17.0330561
|
132.7 milimeters of Hg
Standard Deviation 16.38723706
|
116.3636 milimeters of Hg
Standard Deviation 7.364945637
|
120.1364 milimeters of Hg
Standard Deviation 14.54809906
|
120.6522 milimeters of Hg
Standard Deviation 10.01185069
|
126.4545 milimeters of Hg
Standard Deviation 17.25916533
|
PRIMARY outcome
Timeframe: baseline, 0 minutesOutcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Baseline Diastolic Blood Pressure
|
74.1379 milimeters of Hg
Standard Deviation 11.37894088
|
81.7667 milimeters of Hg
Standard Deviation 9.722648048
|
75.25 milimeters of Hg
Standard Deviation 12.09372004
|
79.2 milimeters of Hg
Standard Deviation 15.61345574
|
73.1364 milimeters of Hg
Standard Deviation 9.627814144
|
80.9545 milimeters of Hg
Standard Deviation 11.23547644
|
76.3913 milimeters of Hg
Standard Deviation 5.694807287
|
75.0909 milimeters of Hg
Standard Deviation 12.72758194
|
PRIMARY outcome
Timeframe: 10th minuteDiastolic blood pressure values 5 minutes after local anesthesia injection
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Diastolic Blood Pressure at 10 Minutes
|
74.0345 milimeters of Hg
Standard Deviation 8.398480979
|
75.3667 milimeters of Hg
Standard Deviation 12.09830424
|
75.6875 milimeters of Hg
Standard Deviation 14.74829132
|
79.1 milimeters of Hg
Standard Deviation 15.23497999
|
69.7273 milimeters of Hg
Standard Deviation 10.49798991
|
75.0909 milimeters of Hg
Standard Deviation 6.560408603
|
75.8261 milimeters of Hg
Standard Deviation 7.010720193
|
73.8636 milimeters of Hg
Standard Deviation 10.14793178
|
PRIMARY outcome
Timeframe: 15th minuteDiastolic blood pressure values 10 minutes after local anesthesia injection
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Diastolic Blood Pressure at 15 Minutes
|
72.6897 milimeters of Hg
Standard Deviation 6.876998142
|
74.8 milimeters of Hg
Standard Deviation 9.672154605
|
74.8125 milimeters of Hg
Standard Deviation 13.17729597
|
80.0333 milimeters of Hg
Standard Deviation 13.86217876
|
69.3636 milimeters of Hg
Standard Deviation 9.800609576
|
72.5 milimeters of Hg
Standard Deviation 7.163066648
|
79 milimeters of Hg
Standard Deviation 15.45374329
|
74.1818 milimeters of Hg
Standard Deviation 11.57434093
|
PRIMARY outcome
Timeframe: 20th minuteDiastolic blood pressure values 15 minutes after local anesthesia injection
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Diastolic Blood Pressure at 20 Minutes
|
71.6897 milimeters of Hg
Standard Deviation 7.865400945
|
74.1667 milimeters of Hg
Standard Deviation 9.013718791
|
74.1563 milimeters of Hg
Standard Deviation 11.65390527
|
80.8333 milimeters of Hg
Standard Deviation 13.56465997
|
69.4545 milimeters of Hg
Standard Deviation 6.200823853
|
75.9545 milimeters of Hg
Standard Deviation 8.566141948
|
77 milimeters of Hg
Standard Deviation 9.060403362
|
76.0455 milimeters of Hg
Standard Deviation 14.81144111
|
PRIMARY outcome
Timeframe: 35th minuteDiastolic blood pressure values 30 minutes after local anesthesia injection
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Diastolic Blood Pressure at 35 Minutes
|
70.1379 milimeters of Hg
Standard Deviation 8.140393716
|
74.3667 milimeters of Hg
Standard Deviation 10.37021597
|
73.2813 milimeters of Hg
Standard Deviation 12.59091935
|
75.9 milimeters of Hg
Standard Deviation 12.29859279
|
69.1364 milimeters of Hg
Standard Deviation 7.146730552
|
77.0455 milimeters of Hg
Standard Deviation 7.587441207
|
77.6087 milimeters of Hg
Standard Deviation 7.19051857
|
74.7273 milimeters of Hg
Standard Deviation 8.446931357
|
PRIMARY outcome
Timeframe: baseline, 0 minutesOutcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Baseline Values of Heart Rate
|
75.0345 beats per minute
Standard Deviation 10.80172856
|
80.7727 beats per minute
Standard Deviation 6.682366571
|
78.3438 beats per minute
Standard Deviation 10.20312847
|
84.2581 beats per minute
Standard Deviation 13.16806172
|
76.4545 beats per minute
Standard Deviation 14.44769638
|
73.0333 beats per minute
Standard Deviation 8.695547948
|
76.2174 beats per minute
Standard Deviation 14.04031463
|
76.3636 beats per minute
Standard Deviation 9.756782523
|
PRIMARY outcome
Timeframe: 10th minuteHeart rate 5 minutes after local anesthesia injection, 10 minutes after baseline measurement
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Heart Rate at 10 Minutes
|
75.3448 beats per minute
Standard Deviation 11.45262248
|
81.7727 beats per minute
Standard Deviation 5.72311305
|
83.3125 beats per minute
Standard Deviation 10.35012077
|
88.5806 beats per minute
Standard Deviation 12.72209153
|
74.0455 beats per minute
Standard Deviation 15.06012481
|
73.0667 beats per minute
Standard Deviation 7.671417688
|
83.913 beats per minute
Standard Deviation 14.36811358
|
83.6818 beats per minute
Standard Deviation 13.23554508
|
PRIMARY outcome
Timeframe: 15th minuteHeart rate 10 minutes after local anesthesia injection, 15 minutes after baseline measurement
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Heart Rate at 15 Minutes
|
73.0345 beats per minute
Standard Deviation 10.10828076
|
77.4545 beats per minute
Standard Deviation 6.790883003
|
83.4688 beats per minute
Standard Deviation 10.92196477
|
86.8387 beats per minute
Standard Deviation 12.41261932
|
74.5 beats per minute
Standard Deviation 12.91271061
|
73.4333 beats per minute
Standard Deviation 4.896327805
|
81.6957 beats per minute
Standard Deviation 14.48974013
|
83.5909 beats per minute
Standard Deviation 11.09121957
|
PRIMARY outcome
Timeframe: 20th minuteHeart rate 15 minutes after local anesthesia injection, 20 minutes after baseline measurement
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Heart Rate at 20 Minutes
|
72.2414 beats per minute
Standard Deviation 9.697772839
|
80.2273 beats per minute
Standard Deviation 7.276477612
|
81.3125 beats per minute
Standard Deviation 11.56032565
|
86.1935 beats per minute
Standard Deviation 12.04552297
|
73.6818 beats per minute
Standard Deviation 12.32645766
|
71.8667 beats per minute
Standard Deviation 5.281881142
|
79.8435 beats per minute
Standard Deviation 13.46448997
|
82 beats per minute
Standard Deviation 11.84824681
|
PRIMARY outcome
Timeframe: 35th minuteHeart rate 30 minutes after local anesthesia injection, 35 minutes after baseline measurement
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Ceart Rate at 35 Minutes
|
72.1034 beats per minute
Standard Deviation 9.236359934
|
80.8182 beats per minute
Standard Deviation 6.095127129
|
80.0938 beats per minute
Standard Deviation 11.04348991
|
85.3871 beats per minute
Standard Deviation 11.87062879
|
71.3636 beats per minute
Standard Deviation 12.53393662
|
73.4333 beats per minute
Standard Deviation 7.762157062
|
77 beats per minute
Standard Deviation 13.78017709
|
78.2273 beats per minute
Standard Deviation 12.75382974
|
PRIMARY outcome
Timeframe: baseline, 0 minutesOutcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Baseline Electrocardiogram
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
PRIMARY outcome
Timeframe: 10th minuteECG 5 minutes after local anesthesia injection, 10 minutes after baseline measurement
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Electrocardiogram at 10 Minutes
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
PRIMARY outcome
Timeframe: 15th minuteECG 10 minutes after local anesthesia injection, 15 minutes after baseline measurement
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Electrocardiogram at 15 Minutes
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
PRIMARY outcome
Timeframe: 20th minuteECG 15 minutes after local anesthesia injection, 20 minutes after baseline measurement
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Electrocardiogram at 20 Minutes
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
SECONDARY outcome
Timeframe: Up to 10 minutes, until subjective feeling of soft tissue numbnesEvaluated by pin-prick after subjective feeling of soft tissue numbness appeared after local anesthesia injection
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Onset of Intraoral Local Anesthesia
|
1.76 minutes
Standard Deviation 0.87
|
5.27 minutes
Standard Deviation 2.12
|
2.16 minutes
Standard Deviation 1.08
|
5.45 minutes
Standard Deviation 2.64
|
2.77 minutes
Standard Deviation 1.11
|
4.59 minutes
Standard Deviation 2.58
|
2.83 minutes
Standard Deviation 0.83
|
6.36 minutes
Standard Deviation 2.3
|
SECONDARY outcome
Timeframe: Up to 10 minutes after injection of local anesthesiaSoft tissue numbness area determined by pin-prick test after maxillary infiltration anesthesia. Not tested for mandibular ablock anesthesia.
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Width of Anesthetic Field After Maxillary Infiltration Anesthesia
|
27.07 milimeters
Standard Deviation 1.06
|
NA milimeters
Standard Deviation NA
Measured only after infiltration technique
|
35.19 milimeters
Standard Deviation 1.67
|
NA milimeters
Standard Deviation NA
Measured only after infiltration technique
|
23.81 milimeters
Standard Deviation 1.07
|
NA milimeters
Standard Deviation NA
Measured only after infiltration technique
|
24.52 milimeters
Standard Deviation 0.95
|
NA milimeters
Standard Deviation NA
Measured only after infiltration technique
|
SECONDARY outcome
Timeframe: up to 24 hours after tooth extractionNumber of participants who experienced postoperative pain, VAS, NRS
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Postoperative Analgesia
|
11 Participants
|
15 Participants
|
13 Participants
|
14 Participants
|
5 Participants
|
14 Participants
|
10 Participants
|
12 Participants
|
SECONDARY outcome
Timeframe: 24 hours, 7 daysPostoperative paresthesia by clinical examination
Outcome measures
| Measure |
Diabetics: L+C Maxillary Anesthesia
n=29 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+C Mandibular Anesthesia
n=30 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Diabetics: L+E Maxillary Anesthesia
n=32 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Diabetics: L+E Mandibular Anesthesia
n=31 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+C Maxillary Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for maxillary infiltration anesthesia
L+C maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+C Mandibular Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + clonidine (15 mcg/ml) for mandibular block anesthesia
L+C mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + clonidine (15 mcg/ml)
|
Healthy: L+E Maxillary Anesthesia
n=25 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%)+ epinephrine (1:80.000) for maxillary infiltration anesthesia
L+E maxillary anesthesia: Maxillary anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
Healthy: L+E Mandibular Anesthesia
n=24 Participants
Single dose intraoral local anesthesia with 2ml lidocaine (2%) + epinephrine (1:80.000) for mandibular block anesthesia
L+E mandibular anesthesia: Mandibular anesthesia obtained by 2% lidocaine + epinephrine (1:80 000)
|
|---|---|---|---|---|---|---|---|---|
|
Local Postoperative Complications
|
1 Participants
|
1 Participants
|
6 Participants
|
4 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
0 Participants
|
Adverse Events
Diabetics: L+C Maxillary Anesthesia
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Diabetics: L+C Mandibular Anesthesia
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Diabetics: L+E Maxillary Anesthesia
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Diabetics: L+E Mandibular Anesthesia
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Healthy: L+C Maxillary Anesthesia
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Healthy: L+C Mandibular Anesthesia
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Healthy: L+E Maxillary Anesthesia
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Healthy: L+E Mandibular Anesthesia
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
DDS PhD Professor Dragica Stojic, DDS PhD Professor Bozidar Brkovic, DDS PhD Marija Milic
University of Belgrade, Faculty of Dental Medicine
Phone: + 381 11 2685 280
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place