The Effects of Morphine on Desflurane Consumption and Recovery Time

NCT ID: NCT02362022

Last Updated: 2015-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-09-30

Study Completion Date

2007-12-31

Brief Summary

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Combination of volatile and opioid agents are used to achieve unconsciousness, haemodynamic stability and analgesia for surgical prosedures. This prospective, randomized, double-blind, controlled study evaluates the effects of two different doses of morphine sulphate (0.1 mg/kg and 0.2 mg/kg), on desflurane consumption, recovery characteristics, postoperative analgesic requirements and side effects during total abdominal hysterectomy.

Detailed Description

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Conditions

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Abdominal Hysterectomy (& Wertheim)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Caregivers Investigators

Study Groups

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Group Saline

Group Saline (Group S) received i.v saline 0.9 % in 10 ml volume (n=30)

Group Type PLACEBO_COMPARATOR

Morphine

Intervention Type DRUG

Group Saline (Group S): Received i.v saline 0.9 % in 10 ml volume (n=30) Group Morphine 1 (Group M1): Received i.v morphine 0.1 mg kg-1 in 10 ml volume (n=30) Group Morphine 2 (Group M2): Received i.v morphine 0.2 mg kg-1 in 10 ml volume (n=30)

Group Morphine 1

Group Morphine 1 (Group M1) received i.v morphine 0.1 mg kg-1, in 10 ml volume (n=30)

Group Type ACTIVE_COMPARATOR

Morphine

Intervention Type DRUG

Group Saline (Group S): Received i.v saline 0.9 % in 10 ml volume (n=30) Group Morphine 1 (Group M1): Received i.v morphine 0.1 mg kg-1 in 10 ml volume (n=30) Group Morphine 2 (Group M2): Received i.v morphine 0.2 mg kg-1 in 10 ml volume (n=30)

Group Morphine 2

Group Morphine 2 (Group M2) received i.v morphine 0.2 mg kg-1, in 10 ml volume (n=30)

Group Type ACTIVE_COMPARATOR

Morphine

Intervention Type DRUG

Group Saline (Group S): Received i.v saline 0.9 % in 10 ml volume (n=30) Group Morphine 1 (Group M1): Received i.v morphine 0.1 mg kg-1 in 10 ml volume (n=30) Group Morphine 2 (Group M2): Received i.v morphine 0.2 mg kg-1 in 10 ml volume (n=30)

Interventions

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Morphine

Group Saline (Group S): Received i.v saline 0.9 % in 10 ml volume (n=30) Group Morphine 1 (Group M1): Received i.v morphine 0.1 mg kg-1 in 10 ml volume (n=30) Group Morphine 2 (Group M2): Received i.v morphine 0.2 mg kg-1 in 10 ml volume (n=30)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* undergoing total abdominal hysterectomy with general anaesthesia

Exclusion Criteria

* renal dysfunction (cre\>1.2), liver failure, cardiovascular, psychiatric, allergic and metabolic disorders
Minimum Eligible Age

40 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Baskent University

OTHER

Sponsor Role lead

Responsible Party

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CAGLA BALI,MD

medical doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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cagla bali

Role: PRINCIPAL_INVESTIGATOR

Baskent University

Locations

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Baskent University School of Medicine Adana Teaching and Research Hospital

Adana, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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14.09.2007/88-4

Identifier Type: -

Identifier Source: org_study_id