Rate RESPONSIVe Pacing in Patients With Permanent AF Underwent AV Node ABLation and bivEntricular Pacing (RESPONSIBLE)

NCT ID: NCT02354989

Last Updated: 2015-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-01-31

Study Completion Date

2015-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the effect on distance covered in a 6 minute walking test of Rate Responsive pacing in patients with permanent atrial fibrillation and reduced left ventricular ejection fraction treated with atrioventricular junction ablation and biventricular pacing.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Patients with permanent atrial fibrillation and reduced left ventricular ejection fraction treated with atrioventricular junction ablation and biventricular pacing will be enrolled. Two 6' walking test (6WT), one during VVI 70/min biventricular pacing (RR off) and the other during VVIR 70-120/min biventricular pacing (RR on), will be performed one week apart; patients will be randomly and blindly assigned with a 1:1 ratio to group A (first 6WT RR off) or B (first 6WT RR on). The difference between the two tests will be recorded.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Left Ventricular Dysfunction Atrial Fibrillation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

RR on first

Rate Response on first

Group Type ACTIVE_COMPARATOR

Rate Response on first (VVI biventricular pacing)

Intervention Type DEVICE

Rate Response function is turned on in the device. The patients performs a 6 minute walking test. After a week Rate Response function is turned off and the patient performs a second 6 minute walking test.

RR off first

Rate Response off first

Group Type ACTIVE_COMPARATOR

Rate Response off first (VVI biventricular pacing)

Intervention Type DEVICE

Rate Response function is turned off in the device. The patients performs a 6 minute walking test. After a week Rate Response function is turned on and the patient performs a second 6 minute walking test.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Rate Response on first (VVI biventricular pacing)

Rate Response function is turned on in the device. The patients performs a 6 minute walking test. After a week Rate Response function is turned off and the patient performs a second 6 minute walking test.

Intervention Type DEVICE

Rate Response off first (VVI biventricular pacing)

Rate Response function is turned off in the device. The patients performs a 6 minute walking test. After a week Rate Response function is turned on and the patient performs a second 6 minute walking test.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Permanent, refractory atrial fibrillation treated with atrio-ventricular node ablation and biventricular pacing
* Left ventricular systolic dysfunction
* Ability to perform a 6-minute walking test
* Completion of the 18th year of age

Exclusion Criteria

* Contraindications to 6 minute walking test
* IV NYHA Class
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Azienda Ospedaliera Cardinale G. Panico

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Pietro Palmisano, MD

Role: PRINCIPAL_INVESTIGATOR

Azienda Ospedaliera "Card. G. Panico" - Tricase

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Università Politecnica delle Marche

Ancona, Ancona, Italy

Site Status

Policlinico S.Orsola-Malpighi

Bologna, Bologna, Italy

Site Status

AO Pugliese-Ciaccio

Catanzaro, Catanzaro, Italy

Site Status

Azienda Ospedaliera "Card. G. Panico"

Tricase, Lecce, Italy

Site Status

Seconda Università Napoli - A.O. Monaldi

Naples, Naples, Italy

Site Status

AOU "Maggiore della Carità"

Novara, Novara, Italy

Site Status

Ospedale San Filippo Neri

Roma, Roma, Italy

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Italy

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

RESPONSIBLE

Identifier Type: -

Identifier Source: org_study_id