ADVANCE ASO AMPLATZER™ Atrial Septal Occluder Post Market Surveillance Study

NCT ID: NCT02353351

Last Updated: 2019-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

602 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-01-19

Study Completion Date

2017-02-24

Brief Summary

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Prospective, multicenter, case-cohort study.To identify potential risk factors associated with the occurrence of erosion due to implantation of the AMPLATZER™ Septal Occluder (ASO.)

Detailed Description

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This study will enroll 8000 subjects. The sub-cohort will consist of 160 (2%) subjects, randomly selected from the full cohort. The analysis population will consist of all subjects in the sub-cohort, combined with all subjects with erosion events who are not in the sub-cohort. A detailed assessment of risk factors will be conducted on the subjects in this analysis population.

Conditions

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Atrial Septal Defect Secundum

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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atrial septal occluder

Single arm atrial septal defect closure with the AMPLATZER Septal Occluder

Intervention Type DEVICE

Other Intervention Names

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AMPLATZER Septal Occluder

Eligibility Criteria

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Inclusion Criteria

1. Patient indicated for ASD closure who has echocardiographic evidence of ostium secundum atrial septal defect and clinical evidence of right ventricular volume overload (such as, 1.5:1 degree of left-to-right shunt or RV enlargement) and is implanted with the ASO device Note: This does not include the indication for closure of a fenestration following a fenestrated Fontan procedure
2. Patient is willing and able to complete the follow-up requirements of this study
3. Patient signs the informed consent (or a legal representative signs the informed consent.)

Exclusion Criteria

1. Patient is known to have extensive congenital cardiac anomaly which can only be adequately repaired by way of cardiac surgery
2. Patient is known to have sepsis within 1 month prior to implantation, or any systemic infection that cannot be successfully treated prior to device placement
3. Patient is known to have a bleeding disorder, untreated ulcer, or any other contraindications to aspirin therapy (unless another anti-platelet agent can be administered for 6 months)
4. Patient is known to have a demonstrated intracardiac thrombus on echocardiography
5. Patient whose size (such as, too small for transesophageal echocardiography probe, catheter size) or condition (active infection, etc.) would cause the patient to be a poor candidate for cardiac catheterization
6. Patient has margins of defect that are less than 5 mm to the coronary sinus, AV valves or right upper lobe pulmonary vein
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ashish Oza

Role: STUDY_DIRECTOR

Abbott Medical Devices

Locations

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University of Alabama

Birmingham, Alabama, United States

Site Status

University of Arizona

Tucson, Arizona, United States

Site Status

University of Arkansas

Little Rock, Arkansas, United States

Site Status

Children's Hospital Los Angeles

Los Angeles, California, United States

Site Status

Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, United States

Site Status

University of Southern California

Los Angeles, California, United States

Site Status

Ronald Reagan UCLA Medical Center

Los Angeles, California, United States

Site Status

Valley Children's Hospital

Madera, California, United States

Site Status

Stanford University Medical Center

Palo Alto, California, United States

Site Status

Huntington Memorial Hospital

Pasadena, California, United States

Site Status

Rady Children's Hospital

San Diego, California, United States

Site Status

Yale New Haven Hospital

New Haven, Connecticut, United States

Site Status

Nemours/Alfred I. duPont Hospital for Children

Wilmington, Delaware, United States

Site Status

Children's National Medical Center

Washington D.C., District of Columbia, United States

Site Status

Clearwater Cardiovascular Consultants

Clearwater, Florida, United States

Site Status

Baptist Medical Center

Jacksonville, Florida, United States

Site Status

Florida Hospital Orlando

Orlando, Florida, United States

Site Status

Arnold Palmer Hospital for Children

Orlando, Florida, United States

Site Status

All Children's Hospital

St. Petersburg, Florida, United States

Site Status

Tampa General Hospital

Tampa, Florida, United States

Site Status

Children's Healthcare of Atlanta

Atlanta, Georgia, United States

Site Status

Advocate Christ Medical Center

Oak Lawn, Illinois, United States

Site Status

Riley Hospital for Children

Indianapolis, Indiana, United States

Site Status

Iowa Heart Center / Mercy Medical Center

West Des Moines, Iowa, United States

Site Status

Children's Hospital

New Orleans, Louisiana, United States

Site Status

University of Maryland

Baltimore, Maryland, United States

Site Status

Boston Children's Hospital

Boston, Massachusetts, United States

Site Status

Children's Hospital of Michigan

Detroit, Michigan, United States

Site Status

Henry Ford Hospital

Detroit, Michigan, United States

Site Status

Children's Hospitals and Clinics of Minnesota

Minneapolis, Minnesota, United States

Site Status

University of Mississippi Medical Center

Jackson, Mississippi, United States

Site Status

St. Louis Children's Hospital

St Louis, Missouri, United States

Site Status

Sunrise Hospital

Las Vegas, Nevada, United States

Site Status

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, United States

Site Status

Albany Medical College

Albany, New York, United States

Site Status

Cohen Children's Medical Center

New Hyde Park, New York, United States

Site Status

New York Presbyterian/Cornell

New York, New York, United States

Site Status

Mount Sinai Hospital

New York, New York, United States

Site Status

Children's Hospital of New York - Presbyterian

New York, New York, United States

Site Status

University of North Carolina

Chapel Hill, North Carolina, United States

Site Status

Duke University Hospital

Durham, North Carolina, United States

Site Status

East Carolina University

Greenville, North Carolina, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

Nationwide Children's Hospital

Columbus, Ohio, United States

Site Status

The Ohio State University

Columbus, Ohio, United States

Site Status

University of Oklahoma

Oklahoma City, Oklahoma, United States

Site Status

Holy Spirit Hospital

Camp Hill, Pennsylvania, United States

Site Status

Geisinger Medical Center

Danville, Pennsylvania, United States

Site Status

Pinnacle Health

Harrisburg, Pennsylvania, United States

Site Status

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Site Status

University of Pennslyvania

Philadelphia, Pennsylvania, United States

Site Status

Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, United States

Site Status

North Austin Medical Center

Austin, Texas, United States

Site Status

Driscoll Children's Hospital

Corpus Christi, Texas, United States

Site Status

Houston Methodist DeBakey Heart and Vascular Center

Houston, Texas, United States

Site Status

Texas Children's Hospital / Baylor College of Medicine

Houston, Texas, United States

Site Status

The University of Texas Health Science Center at Houston/Memorial Hermann Hospital

Houston, Texas, United States

Site Status

Primary Children's Hospital

Salt Lake City, Utah, United States

Site Status

University of Virginia

Charlottesville, Virginia, United States

Site Status

Inova Fairfax Hospital

Falls Church, Virginia, United States

Site Status

Seattle Children's Hospital

Seattle, Washington, United States

Site Status

University of Washington

Seattle, Washington, United States

Site Status

Providence Medical Research Group

Spokane, Washington, United States

Site Status

University of Wisconsin

Madison, Wisconsin, United States

Site Status

Aurora St. Luke's Medical Center

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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PS130046

Identifier Type: -

Identifier Source: org_study_id

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