Neuronal and Behavioral Effects of Implicit Priming in Obese Individuals
NCT ID: NCT02347527
Last Updated: 2022-09-07
Study Results
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View full resultsBasic Information
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COMPLETED
NA
92 participants
INTERVENTIONAL
2013-05-31
2019-08-31
Brief Summary
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Detailed Description
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The project goals are to determine the impact of the implicit priming intervention on both brain responses to food cues and on food intake behaviors in overweight/obese individuals. Food image ratings were assessed before and after either (a) an active implicit priming intervention or (b) a control intervention. One group of participants (n = 47; "MRI sample") completed the intervention during an fMRI scan and completed a visual food cues task both before and after the intervention (during fMRI), to assess intervention-related change in neuronal responses to food cues. In this group, food intake measures were also taken following fMRI. In a separate group of participants (n = 45; "Behavioral-only sample"), the primary outcome measure was the change in food image ratings from pre- to post-intervention; fMRI and measures of food intake were not assessed in this group.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Active Implicit Priming (MRI sample)
Participants will complete active implicit priming, in which food images are implicitly primed (i.e., below conscious awareness) with images of positive or negative affect. In addition to measures of food image ratings, this group completed a visual food cues scan during fMRI to assess change in neuronal response to food cues. They also completed a measure of food intake post-intervention.
Active Implicit Priming
A 10-minute implicit priming intervention, associating food images with images of positive or negative valence.
Control Implicit Priming (MRI sample)
Participants will complete a control implicit priming intervention, which matches the active intervention, but with neutral stimuli as primes. In addition to measures of food image ratings, this group completed a visual food cues scan during fMRI to assess change in neuronal response to food cues. They also completed a measure of food intake post-intervention.
Control Implicit Priming
A 10-minute implicit priming intervention, associating food images with images of neutral valence.
Active Implicit Priming (Behavioral-only sample)
Participants will complete active implicit priming, in which food images are implicitly primed (i.e., below conscious awareness) with images of positive or negative affect.
Active Implicit Priming
A 10-minute implicit priming intervention, associating food images with images of positive or negative valence.
Control Implicit Priming (Behavioral-only sample)
Participants will complete a control implicit priming intervention, which matches the active intervention, but with neutral stimuli as primes.
Control Implicit Priming
A 10-minute implicit priming intervention, associating food images with images of neutral valence.
Interventions
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Active Implicit Priming
A 10-minute implicit priming intervention, associating food images with images of positive or negative valence.
Control Implicit Priming
A 10-minute implicit priming intervention, associating food images with images of neutral valence.
Eligibility Criteria
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Inclusion Criteria
* Healthy weight adults
Exclusion Criteria
* Currently dieting
21 Years
65 Years
ALL
Yes
Sponsors
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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
University of Colorado, Denver
OTHER
Responsible Party
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Principal Investigators
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Jason R Tregellas, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
Kristina T Legget, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
Locations
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University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States
Countries
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References
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Legget KT, Cornier MA, Erpelding C, Lawful BP, Bear JJ, Kronberg E, Tregellas JR. An implicit priming intervention alters brain and behavioral responses to high-calorie foods: a randomized controlled study. Am J Clin Nutr. 2022 Apr 1;115(4):1194-1204. doi: 10.1093/ajcn/nqac009.
Legget KT, Cornier MA, Rojas DC, Lawful B, Tregellas JR. Harnessing the power of disgust: a randomized trial to reduce high-calorie food appeal through implicit priming. Am J Clin Nutr. 2015 Aug;102(2):249-55. doi: 10.3945/ajcn.115.106955. Epub 2015 Jun 24.
Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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