Interactive Tool for Informed Consent

NCT ID: NCT02332837

Last Updated: 2021-03-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2019-07-31

Study Completion Date

2020-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Online trials require informed consent from participants. Massive online trials make face-to-face signed consent unrealistic and existing consent comprehension could be improved to increase participant safety and understanding.

This trial will compare understanding of traditional digital consent with multi-media consent and with consent that is multi-media and interactive and uses a test and train model.

The computer will assign participants to 1 of 3 methods to present online consent to participants

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Online trials require informed consent from participants. Massive online trials make face-to-face signed consent unrealistic and existing consent comprehension could be improved to increase participant safety.

Without accurate knowledge decision-making is not informed. Informed consent for participation in research is part of this process. In online trials the opportunity for face-to-face signed consent with researchers is not an option.

Consent acts as a safeguard that full disclosure occurred. Adequate documentation is evidence against false reports of coercion.

Informed consent inclusive of signed participant information sheets provide a record between researcher and participant of the roles and agreements they share.

According to existing research, only 6% of consents and participant information sheets are written below an eighth grade level of comprehension; 54% of participants with an 8th grade level education partially understood the consent with figures rising to 72% for participants with greater than 8th grade educations, however no participant fully understood the consent materials. The deficits ranged from misunderstandings about risk, side effects, adverse effects reporting, a participants right to withdraw, confidentiality and even the purpose of the trial.

This trial will compare understanding of traditional digital consent with multi-media consent and with consent that is multi-media and interactive and uses a test and train model.

The computer will assign participants to 1 of 3 methods to present online consent to participants

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Informed Consent

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Digital informed consent

Traditional digitally signed text based informed consent

Intervention A: questionnaire accuracy Intervention B: Questionnaire speed of completion Intervention C: Questionnaire completion rate

Group Type EXPERIMENTAL

Intervention A: Questionnaire accuracy

Intervention Type BEHAVIORAL

Participants will be tested by questionnaire to measure how well consent is understood

Intervention B: Questionnaire speed of completion

Intervention Type BEHAVIORAL

Time to complete questionnaire from time of presentation

Intervention C: Questionnaire Completion rate

Intervention Type BEHAVIORAL

Number of participants who complete the questionnaire

Multi-media informed consent

Informed consent with images, text and auditory presentation

Intervention A: questionnaire accuracy Intervention B: Questionnaire speed of completion Intervention C: Questionnaire completion rate

Group Type EXPERIMENTAL

Intervention A: Questionnaire accuracy

Intervention Type BEHAVIORAL

Participants will be tested by questionnaire to measure how well consent is understood

Intervention B: Questionnaire speed of completion

Intervention Type BEHAVIORAL

Time to complete questionnaire from time of presentation

Intervention C: Questionnaire Completion rate

Intervention Type BEHAVIORAL

Number of participants who complete the questionnaire

Test to train informed consent

Informed consent with images, text, auditory presentation and test to train feature where participants get feedback on comprehension responses throughout the consent and can change them

Intervention A: questionnaire accuracy Intervention B: Questionnaire speed of completion Intervention C: Questionnaire completion rate

Group Type EXPERIMENTAL

Intervention A: Questionnaire accuracy

Intervention Type BEHAVIORAL

Participants will be tested by questionnaire to measure how well consent is understood

Intervention B: Questionnaire speed of completion

Intervention Type BEHAVIORAL

Time to complete questionnaire from time of presentation

Intervention C: Questionnaire Completion rate

Intervention Type BEHAVIORAL

Number of participants who complete the questionnaire

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Intervention A: Questionnaire accuracy

Participants will be tested by questionnaire to measure how well consent is understood

Intervention Type BEHAVIORAL

Intervention B: Questionnaire speed of completion

Time to complete questionnaire from time of presentation

Intervention Type BEHAVIORAL

Intervention C: Questionnaire Completion rate

Number of participants who complete the questionnaire

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* pre-screened as eligible for a ThinkWell PLOT trial
* 18 years of age
* No personal email address

Exclusion Criteria

* not pre-screened or eligible for an existing ThinkWell PLOT trial
* people without internet access
* People who cannot read
* People without the ability to understand the website and informed consent documents
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

ThinkWell

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

References

Explore related publications, articles, or registry entries linked to this study.

Ryan RE, Prictor MJ, McLaughlin KJ, Hill SJ. Audio-visual presentation of information for informed consent for participation in clinical trials. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD003717. doi: 10.1002/14651858.CD003717.pub2.

Reference Type BACKGROUND
PMID: 18254029 (View on PubMed)

Gillies K, Huang W, Skea Z, Brehaut J, Cotton S. Patient information leaflets (PILs) for UK randomised controlled trials: a feasibility study exploring whether they contain information to support decision making about trial participation. Trials. 2014 Feb 18;15:62. doi: 10.1186/1745-6215-15-62.

Reference Type BACKGROUND
PMID: 24548781 (View on PubMed)

Antoniou EE, Draper H, Reed K, Burls A, Southwood TR, Zeegers MP. An empirical study on the preferred size of the participant information sheet in research. J Med Ethics. 2011 Sep;37(9):557-62. doi: 10.1136/jme.2010.041871. Epub 2011 Apr 8.

Reference Type BACKGROUND
PMID: 21478421 (View on PubMed)

Rowbotham MC, Astin J, Greene K, Cummings SR. Interactive informed consent: randomized comparison with paper consents. PLoS One. 2013;8(3):e58603. doi: 10.1371/journal.pone.0058603. Epub 2013 Mar 6.

Reference Type BACKGROUND
PMID: 23484041 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ThinkWell PLOT-03

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Agent-Enhanced Document Explanation
NCT02668705 TERMINATED NA
Modified Consent Form Utility
NCT00715923 TERMINATED NA