Hyperbaric Oxygen Therapy in Diabetics With Chronic Foot Ulcers and Improvement of Quality of Life

NCT ID: NCT02328508

Last Updated: 2014-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-30

Study Completion Date

2013-06-30

Brief Summary

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This study evaluated the effect of hyperbaric oxygen therapy (HBOT) on wound healing, inflammation index, glycemic control, amputation rate, survival rate of tissue, bacterial wound cultures, and quality of life (QOL) in diabetic foot ulcer (DFU) patients with diabetes.

Detailed Description

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OBJECTIVE - This study evaluated the effect of hyperbaric oxygen therapy (HBOT) on wound healing, inflammation index, glycemic control, amputation rate, survival rate of tissue, bacterial wound cultures, and quality of life (QOL) in diabetic foot ulcer (DFU) patients with diabetes.

RESEARCH DESIGN AND METHODS - This study was a randomized, single-center clinical trial. The effects of HBOT on patients in the experimental group were compared with the control group received only routine care. HBOT was carried out in a hyperbaric chamber for 120-min per session, five days a week for four consecutive weeks (20 treatment sessions). Data were collected at 4 segments: pre-treatment (before first administration of HBOT; T1), during treatment (at the tenth administration of HBOT; T2), post-treatment (at the twentieth administration of HBOT; T3), and treatment follow-up (two weeks after the last therapy ended; T4).

Conditions

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Diabetic Foot Ulcer Diabetes

Keywords

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hyperbaric oxygen therapy diabetic foot ulcer wound healing inflammation glycemic control amputation bacterial infection quality of life

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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hyperbaric oxygen therapy

The experimental group received treatments in a hyperbaric chamber for 120-min per session, once per day, and five days per week for four consecutive weeks (20 treatment sessions).

Group Type EXPERIMENTAL

Hyperbaric oxygen therapy

Intervention Type DEVICE

HBOT was carried out in a hyperbaric chamber for 120-min per session, five days a week for four consecutive weeks (20 treatment sessions).

Control

The control group received only routine care.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Hyperbaric oxygen therapy

HBOT was carried out in a hyperbaric chamber for 120-min per session, five days a week for four consecutive weeks (20 treatment sessions).

Intervention Type DEVICE

Other Intervention Names

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HBOT

Eligibility Criteria

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Inclusion Criteria

* over 20 years of age
* a history of diabetes and a diagnosis of diabetic foot
* a wound classification of Grade 3 or below
* clear conscious and willing to participate in this study
* a signed consent form

Exclusion Criteria

* less than 20 years of age, unwilling to participate
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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I-Shou University

OTHER

Sponsor Role collaborator

Chen-Yu Chen

OTHER

Sponsor Role lead

Responsible Party

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Chen-Yu Chen

Registered Nurse

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Chen-Yu Chen, Master

Role: PRINCIPAL_INVESTIGATOR

Chang Gung Memorial Hospital

Other Identifiers

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100-0876B, 101-0507C

Identifier Type: -

Identifier Source: org_study_id