MedDataX Logo

Influence of Epidural Analgesia on Natural Killer Cell (NK) Activity After Colonic Cancer Surgery

NCT ID: NCT02326727

Last Updated: 2014-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-04-30

Study Completion Date

2017-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Regional anesthesia may decrease the release of endogenous opioids, increase Natural Killer cell (NK) function and decrease development of metastasis. The recent analysis of the Cancer Registry has noted an improved 5-year survival in patients who received epidural analgesia during surgery for colorectal carcinoma.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Colonic Neoplasms

Keywords

Explore important study keywords that can help with search, categorization, and topic discovery.

Epidural Analgesia Natural Killer Cells

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

General Anesthesia

Patients receiving general anesthesia with Fentanyl,Propofol, Isoflurane and Nitrous Oxide only during colonic cancer surgery

Group Type ACTIVE_COMPARATOR

Fentanyl

Intervention Type DRUG

General Anesthesia

Propofol

Intervention Type DRUG

General Anesthesia

Isoflurane

Intervention Type DRUG

General Anesthesia

Nitrous Oxide

Intervention Type DRUG

General Anesthesia

Combined anesthesia

Patients receiving general anesthesia and epidural analgesia with Ropivacaine during colonic cancer surgery

Group Type ACTIVE_COMPARATOR

Ropivacaine

Intervention Type DRUG

Epidural analgesia

Fentanyl

Intervention Type DRUG

General Anesthesia

Propofol

Intervention Type DRUG

General Anesthesia

Isoflurane

Intervention Type DRUG

General Anesthesia

Nitrous Oxide

Intervention Type DRUG

General Anesthesia

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Ropivacaine

Epidural analgesia

Intervention Type DRUG

Fentanyl

General Anesthesia

Intervention Type DRUG

Propofol

General Anesthesia

Intervention Type DRUG

Isoflurane

General Anesthesia

Intervention Type DRUG

Nitrous Oxide

General Anesthesia

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patients undergoing colonic cancer surgery

Exclusion Criteria

* Patients with poor physical status Patients needed emergency surgery Coagulopathic disorders with international normalized ratio (INR) level more than 1.4 Thrombocytopenia with platelets count less 100000 per mcl Allergic reaction to local anesthetics in patient history Failure to performing the epidural analgesia from another cause Preoperative immunomodulating treatment Recent history of chemotherapy or radiation therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Hillel Yaffe Medical Center

OTHER_GOV

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Hillel Yaffe Medical Center

Hadera, , Israel

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Israel

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Leonid Reytman, MD

Role: CONTACT

Phone: 972-4-6304257

Email: [email protected]

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

0095-14-HYMC

Identifier Type: -

Identifier Source: org_study_id