Cut-Off Progesterone Values Deleterious for In Vitro Fertilization and Fresh Embryo Transfer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1901 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-31

Study Completion Date

2014-03-31

Brief Summary

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At which deleterious cut off value of progesterone on day of HCG (P-hCG) in our IVF program should fresh embryo transfer (ET) be cancelled?

Detailed Description

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There is still an ongoing debate on the effect of subtle increased P-hCG concentration on pregnancy outcome after fresh ET. No consensus on the cut-off value to define increased P-hCG seems to exist. It is accepted that high P advances endometrium, leading to asynchrony between the implanting embryo and the endometrium, and resulting in implantation failure. A freeze all embryos policy and postponement of ET in subsequent frozen-thawed cycle has been proposed.

Conditions

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Progesterone Fertilization in Vitro Infertility Pregnancy

Study Design

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Observational Model Type

CASE_CROSSOVER

Study Time Perspective

RETROSPECTIVE

Interventions

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Progesterone

Progesterone level

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Fresh embryo transfer
* Progesterone value on day HCG (Human choriogonadotrophin hormone)

Exclusion Criteria

* Clinical indication for delaying embryo transfer

Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Responsible Party

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Dr. Francisca Martínez

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Martinez F, Rodriguez I, Devesa M, Buxaderas R, Gomez MJ, Coroleu B. Should progesterone on the human chorionic gonadotropin day still be measured? Fertil Steril. 2016 Jan;105(1):86-92. doi: 10.1016/j.fertnstert.2015.09.008. Epub 2015 Oct 9.

Reference Type DERIVED

PMID: 26453983 (View on PubMed)

Other Identifiers

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PROGEDEX2014

Identifier Type: -

Identifier Source: org_study_id