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The Effect of Desensitizing Agents in In-home or In-office Dental Bleaching

NCT ID: NCT02316080

Last Updated: 2014-12-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

113 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2013-06-30

Brief Summary

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The aim of this project is to evaluate in vitro and in vivo the effect of dental bleaching agents, carbamide peroxide 16% (T1) and hydrogen peroxide 35% (T2) together with desensitizers/remineralizer agents, Sensodyne® dentifrice (D1); experimental dentifrice with 7,5% of Biosilicate micro-particles (D2); Odontis RX® dentifrice (D3); Sorriso® dentifrice (D4); Biosilicate micro-particles paste, 1:1 (D5), Desensebilize Nano P (D6), bioglass type 45S5 paste, 1:1 (D7); GC= distilled water, in the experimental groups: T1/D1; T1/D2; T1/D3; T1/D4; T1/D5; T1/D6; T1/D7; T1/GC e T2/D1; T2/D2; T2/D3; T2/D4; T2/D5; T2/D6; T2/D7; T2/GC. In the in vitro study, microhardness and roughness measurements, and images using scanning electron microscopy (SEM) will be made on samples of bovine dental enamel and dentin (4x4x3mm; n=10 per group) before and after the treatment with the bleaching gels (T1= 14 days/ 04 hours/day; T2=single session) and the desensitizers/remineralizer agents. In the clinical study, the volunteers (n=10 per group) will be evaluated regarding dentin hypersensitivity (DH), using visual analogue scale, before the beginning of the treatments (T1 and T2) and during the next 14 days (1º, 3º, 7º, 10 º e 14º days) in which the desensitizers/remineralizer agents (there´s no control group in the clinical experiments) will be applying. Data will be analysed intra and inter-group, statistically.

Detailed Description

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Background. Tooth sensitivity (TS) is a common side effect of tooth bleaching. The authors conducted a study to evaluate the efficiency of experimental desensitizing agents in reducing TS caused by bleaching agents.

Methods. To test experimental desensitizing agents in TS caused by dental bleaching the authors selected 113 participants without TS and randomly treated them with T1-16% carbamide peroxide (14 days) or T2-35% hydrogen peroxide (single session). The period of the study was 14 days. Participants (in T1 and T2) used domestic-use (DU) or in office (IO) desensitizers (D): Control Group; (DU)- experimental dentifrice with 7,5% of Biosilicate micro-particles-(D1); Sensodyne® dentifrice-(D2); (DU)-Odontis RX Sensiblock® dentifrice-(D3); (IO)-Biosilicate micro-particles paste, 1:1-(D4); (IO)-bioglass type 45S5 paste, 1:1 (D6); (IO)-Desensebilize Nano P-(D6). On days 1, 3, 7, 10 and 14, the authors received the participants to apply IO desensitizers and to record TS with Visual Analogue Scale (VAS). Data was analyzed with two-way ANOVA (considering time and desensitizing as factors) and post-hoc Bonferroni test (α=0.05).

Results. The use of experimental desensitizing agents G2 and G5 did not cause significantly difference in TS comparing to baseline. TS was not significantly different when G2 was used after 16% carbamide peroxide and G5 after 35% hydrogen peroxide application. Self-perception TS values were significantly (p\<0.001) higher than recorded VAS.

Conclusions. Experimental desensitizing agents containing Biosilicate® can prevent TS caused by bleaching agents: in dentifrice form when associated to 16% carbamide peroxide and in paste, when 35% hydrogen peroxide is used.

Conditions

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Dentin Hypersensitivity

Keywords

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dental bleaching dentin sensitivity biomaterials

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Desensitizing therapy

14 groups (7 treated with in-office dental bleaching and 7 treated with home-use dental bleaching) . There will be 7 different types of dessensitizing agents that will be used together with the dental bleaching treatment

Group Type EXPERIMENTAL

Dental bleaching

Intervention Type OTHER

Home-use or in-office dental bleaching was performed in patients that received different types od desensitizing therapy

Dental Bleaching

2 groups of dental bleaching treatment - 16% carbamide peroxide and 35% peroxide

Group Type EXPERIMENTAL

Desensitizing therapy

Intervention Type OTHER

Participants (in T1 and T2) used domestic-use (DU) or in office (IO) desensitizers (D): Control Group; (DU)- experimental dentifrice with 7,5% of Biosilicate micro-particles-(D1); Sensodyne® dentifrice-(D2); (DU)-Odontis RX Sensiblock® dentifrice-(D3); (IO)-Biosilicate micro-particles paste, 1:1-(D4); (IO)-bioglass type 45S5 paste, 1:1 (D6); (IO)-Desensebilize Nano P-(D6).

Interventions

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Dental bleaching

Home-use or in-office dental bleaching was performed in patients that received different types od desensitizing therapy

Intervention Type OTHER

Desensitizing therapy

Participants (in T1 and T2) used domestic-use (DU) or in office (IO) desensitizers (D): Control Group; (DU)- experimental dentifrice with 7,5% of Biosilicate micro-particles-(D1); Sensodyne® dentifrice-(D2); (DU)-Odontis RX Sensiblock® dentifrice-(D3); (IO)-Biosilicate micro-particles paste, 1:1-(D4); (IO)-bioglass type 45S5 paste, 1:1 (D6); (IO)-Desensebilize Nano P-(D6).

Intervention Type OTHER

Other Intervention Names

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Whitness Perfect® Whitness HP® Dentifrice of Biosilicate Sensodyne® dentifrice Odontis RX Sensiblock Biosilicate micro-particles paste, 1:1 Bioglass type 45S5 paste, 1:1 Desensebilize Nano P

Eligibility Criteria

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Inclusion Criteria

1. Patients male or females, aged between 18 and 40 years.
2. Smokers and nonsmokers.
3. Patients with good general health.
4. Patients with good oral health (no changes in hard or soft tissues).
5. Have a minimum of 24 permanent teeth present and no restorations on anterior teeth.

Exclusion Criteria

1. Patients with a medical history marked by chronic use of analgesics, anti-inflammatory and psychotropic drugs.
2. Patients with braces or prostheses or restorations on anterior teeth.
3. Patients with periodontal disease or poor oral hygiene.
4. Patients with prior tooth sensitivity or have made use of desensitizing agents in the last three months.
5. Patients who are pregnant or nursing.
6. Patients with eating disorders or dieting too acidic.
7. Systemic conditions that predispose to tooth sensitivity.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universidade Federal de Sao Carlos

OTHER

Sponsor Role collaborator

University of Sao Paulo

OTHER

Sponsor Role lead

Responsible Party

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Camila Tirapelli

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Camila Tirapelli, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo

Locations

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University of Sao Paulo -Ribeirao Preto Campus

Ribeirão Preto, São Paulo, Brazil

Site Status

Countries

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Brazil

Related Links

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http://www.forp.usp.br/

Dental School of Ribeirao Preto website

Other Identifiers

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Fapesp 2010120326

Identifier Type: -

Identifier Source: org_study_id