Effects of Neuromuscular Electrical Stimulation in Patients With Congestive Heart Failure

NCT ID: NCT02313714

Last Updated: 2014-12-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-09-30

Study Completion Date

2015-12-31

Brief Summary

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This study intends to treat patient with congestive heart failure that are maximized their pharmacological treatment and at heart transplant wait list.

All patients in the treatment arm will receive electric muscular stimulation with a Russian current protocol twice a week for 7 weeks.

The outcome will be assessed by the improvement in quality of life and functional capacity.

Detailed Description

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The neuromuscular electrical stimulation (NMES) has been used as adjuvant treatment in patients with end-stage congestive heart failure. Those patients are limited to perform conventional physical activity and adherence to any every day protocols frequency. The aim of this study was evaluated the effect on functional status and quality of life after NMES treatment using Russian stimulation wave solely twice a week during five weeks period in patients waiting for a heart transplant.

Inclusion criteria:

Age between 30 to 80 years old Congestive heart failure in NYHA class III or IV Ejection fraction lower than 35% Stable clinical status Full pharmacologic treatment

Exclusion criteria:

Unstable angina Ventricular arrhythmia intermittent lameness Inferior limb amputation

Protocol Design:

Patients at waiting list for heart transplant will be invited to participate on protocol of NMES using Russian stimulation wave (2.5 kHz, burst at 50Hz, on/off: 3/9 sec), named NMES group or sham stimulation, named control group. The NMES will be applied for 50 minutes, twice a week on both quadriceps femoral muscles during 7 weeks. The patients will be evaluated every week for distance walked during six minutes walk test (6MWT), heart rate variability, and functional status according to New York Heart Association. All patients were evaluated at the beginning and after completion of the protocol for quality of life with Minnesota Living with Heart Failure Questionnaire (LHFQ).

Conditions

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Heart Failure

Keywords

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heart failure, heart transplant, electrical stimulation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Neuromuscular stimulation

The patients will receive electric muscular stimulation with a Russian current protocol twice a week for 7 weeks.

Group Type EXPERIMENTAL

stimulation wave (2.5 kHz, burst at 50Hz, on/off: 3/9 sec),

Intervention Type DEVICE

All patients in the treatment arm will receive electric muscular stimulation with a Russian current protocol twice a week for 7 weeks.

Sham Group

The patients will receive very low electric muscular stimulation with a no biological or clinical effects

Group Type PLACEBO_COMPARATOR

Sham

Intervention Type DEVICE

very low electric muscular stimulation

Interventions

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stimulation wave (2.5 kHz, burst at 50Hz, on/off: 3/9 sec),

All patients in the treatment arm will receive electric muscular stimulation with a Russian current protocol twice a week for 7 weeks.

Intervention Type DEVICE

Sham

very low electric muscular stimulation

Intervention Type DEVICE

Other Intervention Names

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Neuromuscular stimulation

Eligibility Criteria

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Inclusion Criteria

* patients on waiting list for heart transplant

Exclusion Criteria

* patients that won't accept to participate in the protocol
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Campinas, Brazil

OTHER

Sponsor Role lead

Responsible Party

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Orlando Petrucci

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Maria Carolina Sacilotto, MsC

Role: PRINCIPAL_INVESTIGATOR

University of Campinas

Locations

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University of Campinas

Campinas, São Paulo, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Maria Carolina Sacilotto, MsC

Role: CONTACT

Phone: +55 19 989464664

Email: [email protected]

Orlando Petrucci, MD, PhD

Role: CONTACT

Phone: +55 19 997253335

Email: [email protected]

Facility Contacts

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Maria Carolina Sacilotto, MsC

Role: primary

Other Identifiers

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ENESPHF

Identifier Type: -

Identifier Source: org_study_id