Evaluation of the Safety and Effectiveness of the Oculeve Intranasal Lacrimal Neurostimulator in Patients With Dry Eye

NCT ID: NCT02313454

Last Updated: 2020-01-31

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-11-17

Study Completion Date

2015-04-08

Brief Summary

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The purpose of this study was to evaluate the safety and effectiveness of the Intranasal Tear Neurostimulator applied intranasally compared with the same device applied extranasally (control) in treating the symptoms of dry eye exacerbated by the Controlled Adverse Environment (CAE) Model.

Detailed Description

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Conditions

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Dry Eye Syndromes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Intranasal Application

Intranasal Tear Neurostimulator device, intranasal application for approximately 3 minutes on Day 0 when the participant experienced an Ocular Discomfort Score (ODS) ≥3 at 2 or more consecutive time points in at least one eye during CAE exposure.

Group Type EXPERIMENTAL

Intranasal Tear Neurostimulator

Intervention Type DEVICE

Neurostimulation applied intranasally and extranasally.

Extranasal Application

Intranasal Tear Neurostimulator device, extranasal application for approximately 3 minutes on Day 0 when the participant experienced an ODS ≥3 at 2 or more consecutive time points in at least one eye during CAE exposure.

Group Type SHAM_COMPARATOR

Intranasal Tear Neurostimulator

Intervention Type DEVICE

Neurostimulation applied intranasally and extranasally.

Interventions

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Intranasal Tear Neurostimulator

Neurostimulation applied intranasally and extranasally.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Bilateral dry eyes
* Capable of providing written informed consent

Exclusion Criteria

* Chronic or recurring epistaxis (nosebleeds)
* Uncontrolled systemic disease
* Blood coagulation disorder
* Females who are pregnant, nursing or planning a pregnancy
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ORA, Inc.

INDUSTRY

Sponsor Role collaborator

Allergan

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michelle Senchyna

Role: STUDY_CHAIR

Allergan

Locations

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Andover Eye Associates

Andover, Massachusetts, United States

Site Status

Countries

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United States

Other Identifiers

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OCUN-007

Identifier Type: -

Identifier Source: org_study_id

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