Stem Cell Therapy for Patients With Vascular Occlusive Diseases Such as Diabetic Foot

NCT ID: NCT02304588

Last Updated: 2014-12-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2017-12-31

Brief Summary

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Mesenchymal stem cells with multidirectional differentiation potential,autologous stem cell transplantation into ischemic foot, make its differentiation to form new blood capillary, improve and restore the local blood flow.

Detailed Description

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Conditions

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Diabetic Foot Lower Limb Ischemia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Mesenchymal stem cells

Maximal amount of MSC cells injected: 10-20\*10\^6 cells (up to volume of 20mL, depending on the wound size \& patient weight).

Group Type EXPERIMENTAL

Mesenchymal stem cells

Intervention Type BIOLOGICAL

10-20 x 10\^6 cells/20mL

Interventions

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Mesenchymal stem cells

10-20 x 10\^6 cells/20mL

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* the age of 30-78 years old, men and women there is no limit.
* in accordance with the ministry of health in higher medical colleges and universities teaching material the sixth edition of the annals of diabetic foot diagnostic criteria.
* with severe lower limb ischemia (defined as the resting state of ankle brachial index (ABI) 0.4-0.85, accompanied by resting or intermittent toe line.
* treatment on a voluntary basis, and sign the informed consent.

Exclusion Criteria

* with severe heart, liver, kidney, lung function failure or general condition is very poor can't tolerate the stem cell transplant.
* clear over the past five years tumor markers in patients with malignant disease and blood levels increased significantly.
* the prodrome of acute infectious diseases.
* participated in clinical subjects within three months before test.
* adherence is poor, can not complete the course.
Minimum Eligible Age

30 Years

Maximum Eligible Age

78 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chinese PLA General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Xiaobing Fu

Academician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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xiaobing FU

Role: PRINCIPAL_INVESTIGATOR

Chinese PLA General Hospital

Locations

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Chinese PLA General Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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xiaobing FU

Role: CONTACT

+86(10)937516

Facility Contacts

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haojie Hao

Role: primary

+86(10)937516

haojie Hao

Role: backup

+86(10)937516

Other Identifiers

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CHIN-PLAGH-ST-001

Identifier Type: -

Identifier Source: org_study_id