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Cardiac Magnetic Resonance in Acute Myocarditis

NCT ID: NCT02299856

Last Updated: 2015-12-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-03-31

Study Completion Date

2015-09-30

Brief Summary

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Cardiac magnetic resonance (MR) is an established noninvasive diagnostic tool for detection of acute myocarditis. Diagnosis of myocarditis at 1.5T is currently made with the help of the Lake Louise Criteria (two of three criteria have to be positive in order to establish the diagnosis). Although these criteria are accepted and widely used in clinical routine, several disadvantages exist. Newer parameters like myocardial T1 and T2 mapping, extracellular volume fraction (ECV) and myocardial strain analysis have the potential to complement or even replace some of the Lake Louise Criteria and further enhance the diagnostic performance of cardiac MR in patients suspected of having acute myocarditis. The aim of our study is to evaluate the diagnostic performance of a comprehensive cardiac MR protocol in patients with acute myocarditis.

Detailed Description

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Conditions

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Myocarditis

Keywords

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Magnetic Resonance Imaging Diagnostic Imaging

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Myocarditis

Patients with strong clinical evidence for acute myocarditis (recent infection, elevated troponin and white blood cell count).

Cardiac magnetic resonance scan

Intervention Type OTHER

Healthy Controls

Healthy volunteers without any signs of cardiac disease.

Cardiac magnetic resonance scan

Intervention Type OTHER

Interventions

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Cardiac magnetic resonance scan

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* No past medical history of cardiac disease.
* No cardiovascular risk factors (e.g. diabetes or hypertension)

Exclusion Criteria

* Contraindications for cardiac MR
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Bonn

OTHER

Sponsor Role lead

Responsible Party

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Claas P. Naehle

PD Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Bonn, Dept. of Radiology

Bonn, North Rhine-Westphalia, Germany

Site Status

Countries

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Germany

References

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Luetkens JA, Doerner J, Thomas DK, Dabir D, Gieseke J, Sprinkart AM, Fimmers R, Stehning C, Homsi R, Schwab JO, Schild H, Naehle CP. Acute myocarditis: multiparametric cardiac MR imaging. Radiology. 2014 Nov;273(2):383-92. doi: 10.1148/radiol.14132540. Epub 2014 Jun 6.

Reference Type BACKGROUND
PMID: 24910904 (View on PubMed)

Luetkens JA, Homsi R, Sprinkart AM, Doerner J, Dabir D, Kuetting DL, Block W, Andrie R, Stehning C, Fimmers R, Gieseke J, Thomas DK, Schild HH, Naehle CP. Incremental value of quantitative CMR including parametric mapping for the diagnosis of acute myocarditis. Eur Heart J Cardiovasc Imaging. 2016 Feb;17(2):154-61. doi: 10.1093/ehjci/jev246. Epub 2015 Oct 16.

Reference Type DERIVED
PMID: 26476398 (View on PubMed)

Other Identifiers

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150/13.2

Identifier Type: -

Identifier Source: org_study_id