Effect of Valsartan vs Perindopril on HOMA-IR Index in Patients With Chronic Kidney Disease
NCT ID: NCT02299310
Last Updated: 2014-12-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
60 participants
INTERVENTIONAL
2014-11-30
2015-12-31
Brief Summary
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Detailed Description
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Every time before and after each medication, HOMA-IR index and other parameters and safety of Valsartan (80mg) and Perindopril (4mg) is performed using a blood sample and conducting some tests (vital signs, physical exam, ECG, laboratory test, etc.) respectively.
Conditions
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Study Design
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NON_RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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Valsartan
Valsartan 80mg/tablet, 1 tablet once daily (crossover)
Valsartan
Valsartan 80mg/tablet, 1 tablet once daily (crossover)
Perindopril
Perindopril 4mg/tablet, 1 tablet once daily (crossover)
Perindopril
Perindopril 4mg/tablet, 1 tablet once daily (crossover)
Interventions
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Valsartan
Valsartan 80mg/tablet, 1 tablet once daily (crossover)
Perindopril
Perindopril 4mg/tablet, 1 tablet once daily (crossover)
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Serum creatinine:1\~3mg/dl
Exclusion Criteria
* Patients treated with corticosteroids or immunosuppressants
* BMI\>30kg/m2
* SP\>180mmHg, DP\>110mmHg
* Patients with serious medical problems requiring specific medical treatment
ALL
No
Sponsors
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Chinese PLA General Hospital
OTHER
Responsible Party
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Ri-Bao Wei
Nephrology
Principal Investigators
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RiBao Wei, Master
Role: STUDY_CHAIR
Department of Nephrology, Chinese PLA General Hospital
Locations
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Chinese PLA General Hospital
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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References
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Satirapoj B, Leelasiri K, Supasyndh O, Choovichian P. Short-term administration of an angiotensin II receptor blocker in patients with long-term hemodialysis patients improves insulin resistance. J Med Assoc Thai. 2014 Jun;97(6):574-81.
Ushijima K, Takuma M, Ando H, Ishikawa-Kobayashi E, Nozawa M, Maekawa T, Shiga T, Fujimura A. Effects of telmisartan and valsartan on insulin sensitivity in obese diabetic mice. Eur J Pharmacol. 2013 Jan 5;698(1-3):505-10. doi: 10.1016/j.ejphar.2012.11.022. Epub 2012 Nov 27.
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T. Valsartan, independently of AT1 receptor or PPARgamma, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E286-96. doi: 10.1152/ajpendo.00324.2011. Epub 2011 Nov 1.
Other Identifiers
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S2014-088
Identifier Type: -
Identifier Source: org_study_id