A Study of Atezolizumab (MPDL3280A) in Combination With Epacadostat (INCB024360) in Subjects With Previously Treated Stage IIIB or Stage IV Non-Small Cell Lung Cancer and Previously Treated Stage IV Urothelial Carcinoma (ECHO-110)

NCT ID: NCT02298153

Last Updated: 2017-12-11

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE1
• Total Enrollment: 29 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-11-30
• Study Completion Date: 2017-11-08

Brief Summary

This study will evaluate the safety and tolerability of epacadostat (INCB024360) administered in combination with atezolizumab (MPDL3280A) in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) that have been previously treated with platinum-based chemotherapy and Stage IV urothelial carcinoma who have failed a platinum-based chemotherapy regimen. The study will be conducted in two phases. The dose escalation phase will utilize a 3 + 3 design to identify the maximum tolerated dose (MTD) or a Pharmacologically Active Dose (PAD) of the combination. This will be followed by a dose expansion phase, which will be comprised of three cohorts. Expansion Cohorts 1 & 2 will further evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics at the dose identified in phase one. Expansion Cohort 3 will evaluate the change in biomarker expression following treatment with epacadostat as monotherapy followed by epacadostat and atezolizumab administered in combination.

Conditions

NSCLC (Non-small Cell Lung Carcinoma); UC (Urothelial Cancer)

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

atezolizumab (MPDL3280A) + epacadostat (INCB024360)

atezolizumab (MPDL3280A) 1200 mg given every 3 weeks + epacadostat (INCB024360) 25 mg BID as starting dose, followed by dose escalations until MTD or PAD is identified

Group Type: EXPERIMENTAL

atezolizumab

Intervention Type: DRUG

atezolizumab: administered intravenously (IV) every three weeks (q3w)

epacadostat

Intervention Type: DRUG

epacadostat: Oral daily dosing

Interventions

atezolizumab

atezolizumab: administered intravenously (IV) every three weeks (q3w)

Intervention Type: DRUG

epacadostat

epacadostat: Oral daily dosing

Intervention Type: DRUG

Other Intervention Names

MPDL3280A; INCB024360

Eligibility Criteria

Inclusion Criteria

• Male or female subjects, age 18 years or older
• Histologically or cytologically confirmed NSCLC
• Stage IIIB or Stage IV NSCLC who are not candidates for multimodality treatment and have received at least 1 line of standard platinum-based therapy:

• Prior systemic regimens must include at least 2 cycles of a platinum-based therapy and may include platinum therapy used as a radiosensitizer. Maintenance chemotherapy is allowed.
• Tumors with driver mutations (epidermal growth factor receptor mutation positive or anaplastic lymphoma kinase fusion oncogene positive) should have had disease progression or been intolerant to the standard tyrosine-kinase inhibitor (TKI), and should include a second line TKI where such therapy is available and indicated.
• Subjects initially treated with a platinum regimen for Stage IIIB disease who later develop metastatic disease and are re-treated with a platinum regimen are allowed.
• Histologically or cytologically confirmed urothelial carcinoma.
• Stage IV locally advanced or metastatic urothelial carcinoma with disease progression during or following platinum-containing chemotherapy or had disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy.
• Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1.
• Presence of measurable disease per RECIST v1.1
• Availability of an adequate archival tumor specimen or willingness to undergo a pretreatment tumor biopsy.
• Subjects enrolled in Expansion Cohort 3 must be willing to have 2 on-treatment tumor biopsies.
• For males and females of child-bearing potential, willingness to use adequate birth control through 90 days after the last dose of epacadostat or atezolizumab.

Exclusion Criteria

• Laboratory and medical history parameters not within protocol-defined range.
• Current treatment with an investigational study drug or immunological-based agent for any reason, or receipt of anticancer medication within 21 days or 5 half-lives (whichever is longer) before first dose.
• Prior treatment with immune checkpoint inhibitors (eg, anti-CTLA-4, anti-PD-1, anti-PD-L1, and any other antibody or drug specifically targeting T-cell co-stimulation) or an IDO inhibitor.
• Prior monoclonal antibody within 4 weeks before study Day 1, or has not recovered from adverse events due to agents administered more than 4 weeks earlier.
• Has an active or inactive autoimmune process.
• Has a history of pneumonitis or idiopathic pulmonary fibrosis, or evidence of interstitial lung disease.
• Prior radiotherapy within 2 weeks of therapy; Must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis.
• Untreated central nervous system (CNS) metastases or CNS metastases that have progressed after completion of radiotherapy.
• Use of systemic corticosteroids ≤ 2 weeks before Cycle 1 Day 1.
• Currently pregnant or breastfeeding.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hoffmann-La Roche

INDUSTRY

Sponsor Role: collaborator

Genentech, Inc.

INDUSTRY

Sponsor Role: collaborator

Incyte Corporation

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Hiroomi Tada, MD

Role: STUDY_DIRECTOR

Incyte Corporation

Locations

Pinnacle Oncology Hematology

Scottsdale, Arizona, United States

Yale University

New Haven, Connecticut, United States

Harvard-Mass General Hospital

Boston, Massachusetts, United States

Dana Farber Cancer Institute

Boston, Massachusetts, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

University of Washington

Seattle, Washington, United States

Countries

United States

Other Identifiers

INCB 24360-110 / ECHO-110

Identifier Type: -

Identifier Source: org_study_id