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Effects of NAVA and PSV to AECOPD Patients' Air Distribution and Dead Space

NCT ID: NCT02289573

Last Updated: 2014-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE3

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-11-30

Study Completion Date

2015-06-30

Brief Summary

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Chronic obstructive pulmonary disease(COPD) is a common disease among people. Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is the acute and aggravating phase of COPD which may lead to respiratory failure. Mechanical ventilation is a very important therapy for those patients,but traditional ventilation modes have some defects, so investigators need to find new modes to solve these problems. In this study, the investigators compare neurally adjusted ventilatory assist (NAVA) and PSV to observe the effects on AECOPD patients' air distribution and dead space to determine if NAVA is a more appropriate ventilation mode for AECOPD patients.

Detailed Description

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Conditions

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Chronic Obstructive Pulmonary Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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neurally adjusted ventilatory assist

Group Type EXPERIMENTAL

NAVA and PSV

Intervention Type DEVICE

change ventilation modes(NAVA and PSV) with different support levels

pressure support ventilation

Group Type SHAM_COMPARATOR

NAVA and PSV

Intervention Type DEVICE

change ventilation modes(NAVA and PSV) with different support levels

Interventions

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NAVA and PSV

change ventilation modes(NAVA and PSV) with different support levels

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* AECOPD patients who need invasive mechanical ventilation
* Patients who can tolerate assist mechanical ventilation
* Patients who have signed ICF

Exclusion Criteria

* Patients who are younger than 18 years old or older than 75 years old
* Patients whose respiratory center is severely inhibited
* Patients who can not stand NAVA gastric tube
* Patients who have coagulation disorders
* Patients whose vital signs are unstable
* Patients who are in other clinical trails
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Southeast University, China

OTHER

Sponsor Role lead

Responsible Party

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Jianfeng Xie

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Sun Q, Liu L, Pan C, Zhao Z, Xu J, Liu A, Qiu H. Effects of neurally adjusted ventilatory assist on air distribution and dead space in patients with acute exacerbation of chronic obstructive pulmonary disease. Crit Care. 2017 Jun 2;21(1):126. doi: 10.1186/s13054-017-1714-1.

Reference Type DERIVED
PMID: 28578708 (View on PubMed)

Other Identifiers

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2014ZDSYLL086.0

Identifier Type: -

Identifier Source: org_study_id