Spanish Retrospective Study to Evaluate the Efficacy and Safety of Targeted Therapies After Pazopanib as First-line Therapy

NCT ID: NCT02282579

Last Updated: 2018-04-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-10-31

Study Completion Date

2015-04-30

Brief Summary

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The purpose of this retrospective observational study was to analyze the effect of targeted therapies administered as second-line treatment after failure of pazopanib as well as increase the amount of information available on efficacy and safety of pazopanib as a first-line therapy in practice usual for the clinical treatment of metastatic Renal Carcinoma.

Detailed Description

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Conditions

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Metastatic Renal Cell Carcinoma

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patient with metastatic renal cell carcinoma treated

Patient with metastatic renal cell carcinoma treated with Pazopanib

Pazopanib

Intervention Type DRUG

Non interventional study

Interventions

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Pazopanib

Non interventional study

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients ≥ 18.
* Metastatic renal cell cancer of any histology.
* Patients treated with pazopanib for metastatic cell renal cancer outside the context of clinical trials (clinical practice) in Spanish centers from 1 April 2011 until 30 June 2014. shall be included all patients who received pazopanib as first-line treatment in each participating center, whether had experienced treatment failure with pazopanib or were still in first-line treatment. The inclusion of patients who are also allowed received cytokine as first-line treatment followed by pazopanib as well as patients who received sunitinib as first-line treatment and have changed pazopanib for toxicity or intolerance, provided they have not received more a cycle of sunitinib.

Exclusion Criteria

* Patients who received pazopanib in clinical trials or treatment second line, with the exceptions noted above.
* Patients with the diagnosis and / or treatment of malignancies of importance other than Cell renal cancer.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Spanish Oncology Genito-Urinary Group

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jose Arranz, PhD

Role: PRINCIPAL_INVESTIGATOR

Investigator coordinator

Locations

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Hospital Son Espases

Palma de Mallorca, Mallorca, Spain

Site Status

Hospital Clínic de Barcelona

Barcelona, , Spain

Site Status

Hospital Vall d' Hebron

Barcelona, , Spain

Site Status

Hospital San Pedro de Alcántara

Cáceres, , Spain

Site Status

Hospital G U de Ciudad Real

Ciudad Real, , Spain

Site Status

Hospital Reina Sofía

Córdoba, , Spain

Site Status

Hospital Universitario de Donostia

Donostia / San Sebastian, , Spain

Site Status

Hospital San Cecilio

Granada, , Spain

Site Status

Hospital General Gran Canaria Dr. Negrín

Las Palmas de Gran Canaria, , Spain

Site Status

Hospital de León

León, , Spain

Site Status

Hospital San Pedro Logroño

Logroño, , Spain

Site Status

Hospital Lucus Augusti

Lugo, , Spain

Site Status

Hospital Gregorio Marañon

Madrid, , Spain

Site Status

Fundacion Jimenez Diaz

Madrid, , Spain

Site Status

Hospital Clínico San Carlos

Madrid, , Spain

Site Status

Hospital Quirón

Madrid, , Spain

Site Status

Hospital U Puerta de Hierro Majadahonda

Madrid, , Spain

Site Status

Hospital Universitario 12 de Octubre

Madrid, , Spain

Site Status

Hospital Universitario La Paz

Madrid, , Spain

Site Status

Hospital Provincial de Pontevedra

Pontevedra, , Spain

Site Status

Hospital Clínico Universitario Salamanca

Salamanca, , Spain

Site Status

Hospital Universitario de Canarias

Santa Cruz de Tenerife, , Spain

Site Status

Hospital Marques de Valdecilla

Santander, , Spain

Site Status

Hospital Ntra. Sra. De Valme

Seville, , Spain

Site Status

Hospital Universitario Virgen del Rocío

Seville, , Spain

Site Status

Hospital Virgen de la Salud

Toledo, , Spain

Site Status

Hospital Clínico de Valencia

Valencia, , Spain

Site Status

Hospital Gral Universitario Valencia

Valencia, , Spain

Site Status

Hospital Universitario Dr. Peset

Valencia, , Spain

Site Status

IVO Valencia

Valencia, , Spain

Site Status

Hospital Rio Hortega

Valladolid, , Spain

Site Status

CHUVI ( Vigo)

Vigo, , Spain

Site Status

Hospital Lozano Blesa

Zaragoza, , Spain

Site Status

Hospital Miguel Servet

Zaragoza, , Spain

Site Status

Countries

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Spain

Other Identifiers

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SOG-SPA-2014-02

Identifier Type: -

Identifier Source: org_study_id

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