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Optical Coherence Tomography Quantitative Analysis of Changes in Anterior Chamber After Laser Peripheral Lridotomy

NCT ID: NCT02279472

Last Updated: 2014-10-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-10-31

Study Completion Date

2015-01-31

Brief Summary

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The purpose of this study is to analysis changes in anterior segment morphology after laser peripheral lrldotomy measured by optical coherence tomography, and to evaluate treatment effectiveness

Detailed Description

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In the study ,primary angle closure(PAC) and primary angle closure glaucoma (PACG) will be recruited. Anterior segment optical coherence tomography images captured before and after laser peripheral iridotomy will be analysed to provide objective and reproducible quantification of anterior segment biometric parameters.The outcomes can provide useful information for clinical strategies in the treatment and management of pathology related to angle closure.

Conditions

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Primary Angle Closure Glaucoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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laser peripheral iridotomy

Laser peripheral iridotomy (LPI) is widely regarded as the first-line intervention for either acute or chronic types of angle-closure glaucoma in early stage ,which relieves pupil block and thus flattening the iris contour and widening the drainage angle,performd by Nd.YAG LASER

Group Type OTHER

Laserex Tango Nd:YAG, Ellex-SuperQ Medical, Australia

Intervention Type PROCEDURE

All the patients will be achieved with pilocarpine 1% for pupil constriction, laser peripheral iridotomy(LPI) is performed using the ophthalmic neodymium: yttrium aluminium garnet laser (Laserex Tango Nd:YAG, Ellex-SuperQ Medical, Australia) and an VOLK iridotomy contact lens. After LPI, patients will be given topical prednisolone acetate 0.1% for 7 days.

Interventions

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Laserex Tango Nd:YAG, Ellex-SuperQ Medical, Australia

All the patients will be achieved with pilocarpine 1% for pupil constriction, laser peripheral iridotomy(LPI) is performed using the ophthalmic neodymium: yttrium aluminium garnet laser (Laserex Tango Nd:YAG, Ellex-SuperQ Medical, Australia) and an VOLK iridotomy contact lens. After LPI, patients will be given topical prednisolone acetate 0.1% for 7 days.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1 .The gonioscopy or UBM examination has confirmed the diagnosis of PACS or PAC 2. Intraocular pressure within 10 to 21 mmHg ，C/D≤0.6 3. Visual field is normal or only show paracentral scotoma 4. Vision or corrected visual acuity ≥0.8 5. Refractive degree no more than 200D 6. Exclude other ocular and systemic diseases

\-

Exclusion Criteria

1. Corneal macula and other corneal diseases, ocular surface disease or corneal edema
2. Iridocyclitis
3. Ocular trauma and intraocular operation history
4. No fixationFundus lesions such as diabetic retinopathy or retinal detachment
5. No fixation
6. Ocular or systemic application of cortical steroids -
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Second Xiangya Hospital of Central South University

OTHER

Sponsor Role lead

Responsible Party

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Haomin Luo

Haomin Luo M.d.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xuanchu Duan, Ph.D

Role: STUDY_DIRECTOR

Second Xiangya Hospital of Central South University

Locations

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The Second Xiangya Hospital of Central South University,

Changsha, Hunan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Haomin Luo, Ph.D student

Role: CONTACT

Phone: +86 13875830738

Email: [email protected]

Facility Contacts

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Haomin Luo, Ph.D student

Role: primary

References

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Memarzadeh F, Li Y, Chopra V, Varma R, Francis BA, Huang D. Anterior segment optical coherence tomography for imaging the anterior chamber after laser peripheral iridotomy. Am J Ophthalmol. 2007 May;143(5):877-9. doi: 10.1016/j.ajo.2006.11.055. Epub 2006 Dec 29.

Reference Type BACKGROUND
PMID: 17452177 (View on PubMed)

Lee KS, Sung KR, Shon K, Sun JH, Lee JR. Longitudinal changes in anterior segment parameters after laser peripheral iridotomy assessed by anterior segment optical coherence tomography. Invest Ophthalmol Vis Sci. 2013 May 3;54(5):3166-70. doi: 10.1167/iovs.13-11630.

Reference Type BACKGROUND
PMID: 23599331 (View on PubMed)

Other Identifiers

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SecondXHCSU

Identifier Type: -

Identifier Source: org_study_id