Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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TERMINATED
NA
39 participants
INTERVENTIONAL
2015-05-29
2017-04-05
Brief Summary
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Detailed Description
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Pain reactivity (Visual analog scale,endogenous modulation systems, salivary cortisol, automatic nervous system and behavioral responses to thermal stimulation assessed by an inspired behavior scale.) in adult with autism is tested using an experimental model of pain. Excitatory and inhibitory modulation systems were elicited using a temporal summation test administered before and after activation of the Diffuse Noxious Inhibitory Control (DNIC) by means of a cold-pressor test.
Demographic and clinical data are also collected (sensory profile, sleep disorders and depression inventory).
Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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high functioning Autism
Thermal stimulation with test thermode Thermic stimulations (tonic heat pain stimulation and cold-pressor test) are used to test excitatory and inhibitory pain mechanisms with high functioning Autism
thermode
thermal stimulation with test thermode
witness
Thermic stimulations (tonic heat pain stimulation and cold-pressor test) are used to test excitatory and inhibitory pain mechanisms with a witness
thermode
thermal stimulation with test thermode
Interventions
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thermode
thermal stimulation with test thermode
Eligibility Criteria
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Inclusion Criteria
* consent form signed
* autism diagnosis (CIM 10) from multidisciplinary evaluation (ADI-r, ADOS)
* sibling without autism or developmental disorder
Exclusion Criteria
* pregnancy, breast feeding
* consent form no signed
\- diagnosis of autism or developmental disorder
18 Years
ALL
Yes
Sponsors
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University Hospital, Brest
OTHER
Responsible Party
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Principal Investigators
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Gildas L'HEVEDER, Doctor
Role: PRINCIPAL_INVESTIGATOR
CHRU Brest
Locations
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CHRU Brest
Brest, , France
Countries
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Other Identifiers
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DOUPA (RB 14.035)
Identifier Type: -
Identifier Source: org_study_id