The Laboratory AntiPlatelet Efficacy and Clinical Outcome Registry

NCT ID: NCT02264912

Last Updated: 2020-07-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2016 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-07-31

Study Completion Date

2018-07-31

Brief Summary

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The ongoing LAPCOR (Laboratory AntiPlatelet efficacy and Clinical Outcome Registry) registry was initiated in 2008 at a tertiary care cardiac center, and consecutive patients, who underwent intracoronary stent implantation, have been included regardless of whether percutaneous coronary intervention (PCI) was performed on urgent or elective basis.Patients were included in the registry after having signed an informed consent for participation. No exclusion criterion has been applied for the registry participation. Efficacy of P2Y12 receptor antagonists has been measured by quantitative flow cytometric analysis of vasodilator-stimulated phosphoprotein (VASP) phosphorylation according to the manufacturer protocol (Platelet VASP; Diagnostica Stago, Biocytex, Asnières, France) on a FACScan flow cytometer (Becton Dickinson). Occurrence of major adverse cardiac events at 30 days, 6-months and one year follow up has been investigated.

Detailed Description

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Conditions

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Platelet Aggregation Onhibitors

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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stent-PCI patients

Consecutive patients, who underwent intracoronary stent implantation, have been included regardless of whether percutaneous coronary intervention (PCI) was performed on urgent or elective basis.

antiplatelet drugs - P2Y12 antagonists

Intervention Type DRUG

Interventions

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antiplatelet drugs - P2Y12 antagonists

Intervention Type DRUG

Other Intervention Names

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clopidogrel, prasugrel, ticagrelor

Eligibility Criteria

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Inclusion Criteria

* Patients after stent PCI treated with P2Y12 antagonist
* Written informed consent

Exclusion Criteria

\- None
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Faculty Hospital Kralovske Vinohrady

OTHER_GOV

Sponsor Role lead

Responsible Party

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Zuzana Motovska

Associate Professor, MD. PhD. FESC.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Zuzana Motovska, MD.PhD.

Role: PRINCIPAL_INVESTIGATOR

Faculty Hospital Kralovske Vinohrady

Locations

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Faculty Hospital Kralovske Vinohrady

Prague, , Czechia

Site Status

Countries

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Czechia

References

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Motovska Z, Odvodyova D, Fischerova M, Stepankova S, Maly M, Morawska P, Widimsky P. Renal function assessed using cystatin C and antiplatelet efficacy of clopidogrel assessed using the vasodilator-stimulated phosphoprotein index in patients having percutaneous coronary intervention. Am J Cardiol. 2012 Mar 1;109(5):620-3. doi: 10.1016/j.amjcard.2011.10.019. Epub 2011 Dec 10.

Reference Type RESULT
PMID: 22154314 (View on PubMed)

Motovska Z, Ondrakova M, Doktorova M, Widimsky P. Severe left ventricular systolic dysfunction is independently associated with high on-clopidogrel platelet reactivity. Am J Cardiovasc Drugs. 2014 Aug;14(4):313-8. doi: 10.1007/s40256-014-0074-3.

Reference Type RESULT
PMID: 24728851 (View on PubMed)

Ondrakova M, Knot J, Ulman J, Maly M, Motovska Z. Efficacy of P2Y12 receptor antagonists in patients with atrial fibrillation according to the CHA2DS2VASc score. Int J Cardiol. 2016 Mar 15;207:84-6. doi: 10.1016/j.ijcard.2016.01.039. Epub 2016 Jan 6. No abstract available.

Reference Type RESULT
PMID: 26797336 (View on PubMed)

Motovska Z, Ondrakova M, Bednar F, Knot J, Ulman J, Maly M. Selection of P2Y12 antagonist, treatment initiation, and predictors of high on-treatment platelet reactivity in a "Real World" registry. Thromb Res. 2015 Jun;135(6):1093-9. doi: 10.1016/j.thromres.2015.04.014. Epub 2015 Apr 16.

Reference Type RESULT
PMID: 25917561 (View on PubMed)

Other Identifiers

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05-2008

Identifier Type: -

Identifier Source: org_study_id

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