Influence of Environmental Conditions on In Vitro Fertilization (IVF) Attempts and Induced Pregnancies

NCT ID: NCT02236780

Last Updated: 2017-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

24000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-01-31

Study Completion Date

2018-01-31

Brief Summary

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The main purpose of the study is to assess the impact of environmental conditions on live-birth rates after intraconjugal IVF.

The second purposes are

* to assess the impact on pregnancies (prematurity, preeclampsia);
* to assess the impact on newborn's health (stunted growth);
* to evaluate the consistency of results observed between assisted pregnancies and spontaneous pregnancies.

Detailed Description

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This multicenter epidemiological study aims to analyze the individual standardized clinical records, collected prospectively since 2008 in the medically assisted procreation centers (MAP).

These individual data will be mapped to the environmental data (meteorological and air quality), recorded in the area of residence of the mother at the time of conception and pregnancy, as well as to the socio-economic data.

Choice of centers:

* The study will be proposed to the 106 private or public centers in metropolitan France who are authorized for MAP procedures such as IVF and ICSI.
* Only the centers who perform more than 200 oocyte retrievals per year will be selected to participate in the study.

More than 80% of attempts performed by the selected centers should be available (without missing data) on the induced pregnancies and their outcome (minimum data set for each case: age of man and woman, cause of infertility, technique used, sperm collection method (ejaculation, surgical sperm retrieval techniques), total number of embryos obtained, clinical pregnancy or not, term of pregnancy, weight and height of the child at birth).

Conditions

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In Vitro Fertilisation Environmental Conditions

Keywords

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in vitro fertilisation environmental conditions pregnancy live birth rate

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Intraconjugal IVF and ICSI
* Transfers of frozen embryos after intraconjugal IVF or ICSI

Exclusion Criteria

* IVF and ICSI with sperm donation
* IVF and ICSI with egg donation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UPRES EA 2506 (Santé-Environnement-Vieillissement), France

UNKNOWN

Sponsor Role collaborator

Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alain BEAUCHET, MD

Role: STUDY_CHAIR

Hôpital Ambroise Paré, AP-HP

Philippe AEGERTER, MD, PhD

Role: STUDY_DIRECTOR

Hôpital Ambroise Paré, AP-HP

Rachel LEVY, MD, PhD

Role: STUDY_DIRECTOR

Hôpital Jean Verdier, AP-HP

Locations

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Alain BEAUCHET

Boulogne-Billancourt, Hauts-de-seine, France

Site Status RECRUITING

Countries

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France

Central Contacts

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Alain BEAUCHET, MD

Role: CONTACT

Phone: + 33 (0)1 49 09 56 68

Email: [email protected]

Philippe AEGERTER, MD, PhD

Role: CONTACT

Phone: + 33 01 49 09 58 86

Email: [email protected]

Facility Contacts

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Alain BEAUCHET, MD

Role: primary

Other Identifiers

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AOR13130

Identifier Type: -

Identifier Source: org_study_id