Efficacy and Safety of Tazarotene Gel in Nail Psoriasis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2015-05-31

Brief Summary

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The aim of this study is to determine the efficacy and safety of topical application of the gel compared to placebo in nail psoriasis.

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Detailed Description

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Conditions

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Nail Psoriasis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Tazarotene Gel

once daily

Group Type EXPERIMENTAL

Experimental Tazarotene Gel

Intervention Type DRUG

Placebo Gel

once daily

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Interventions

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Experimental Tazarotene Gel

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Mild to moderate nail psoriasis on at least one fingernail

Exclusion Criteria

* any other skin condition, with a potential to affect the nails or to interfere with evaluation of the disease;
* history of hypersensitivity to retinoids or to other components of the trial medication
* topical treatment of nails with antipsoriatics in the 4 weeks preceding the treatment phase;
* systemic treatment of psoriasis within the three months before the treatment phase of the trial or during the trial
* intralesional steroid injection before the treatment phase of the trial
* phototherapy before the treatment phase of the trial;
* any chronic infection or condition capable of interfering with the conduct of the trial;
* evidence of drug or alcohol abuse;
* symptoms of a clinically significant illness that may influence the outcome of the trial in the four weeks preceding the treatment phase of the trial;
* participation in another clinical trial within the last 4 weeks prior to first treatment in this clinical trial;
* pregnancy or nursing;

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No