Monitoring the Effect of Red Blood Cell Transfusion on Cerebral Oxygen Saturation With Near Infrared Spectroscopy (NIRS) in Critically Ill Patients
NCT ID: NCT02232412
Last Updated: 2015-03-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
25 participants
OBSERVATIONAL
2014-09-30
2015-03-31
Brief Summary
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To date, RBC transfusions have been proven effective in patients with profound anaemia or circulatory shock. However, the impact of the storage process and the so-called storage lesion on oxygen-carrying properties and, hence, the efficacy of RBC transfusion regarding tissue oxygenation are much debated at present. Alterations of RBC physiology have been comprehensively described ex vivo. Reduced deformability, increased adhesiveness and aggregability of stored RBC impair their rheological properties; anaerobic cellular metabolism with reduced contents of 2,3 bisphosphoglycerate and adenosine triphosphate (ATP) increases oxygen affinity and impairs oxygen release to the tissues.
This study aims to monitor the effect RBC transfusion has on the regional cerebral oxygen saturation (rSO2) of critically ill patients. rSO2 will be measured indirectly, using near infrared spectroscopy (NIRS) . Patients will be monitored once it looms that they might require RBC transfusion. The monitoring is continued for the time of transfusion and the hours afterwards.
Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_ONLY
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* 18 yrs and older
Exclusion Criteria
* cerebral ischaemia
* active bleeding
* patients necessitating ongoing resuscitation
* deficient signal of rSO2 impeding its proper valuation
18 Years
ALL
No
Sponsors
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Johann Wolfgang Goethe University Hospital
OTHER
Responsible Party
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Dr Dania Fischer
Dr. Dania Fischer
Principal Investigators
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Kai D Zacharowski, MD, PhD, FRCA
Role: STUDY_DIRECTOR
University Hospital Frankfurt, Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy
Patrick Meybohm, MD
Role: STUDY_CHAIR
University Hospital Frankfurt, Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy
Dania P Fischer, MD
Role: PRINCIPAL_INVESTIGATOR
University Hospital Frankfurt, Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy
Locations
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University Hospital Frankfurt
Frankfurt am Main, Hesse, Germany
Countries
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Other Identifiers
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NIRS-2014
Identifier Type: -
Identifier Source: org_study_id