A Study of IDN-6556 in Cirrhotic Subjects With Portal Hypertension

NCT ID: NCT02230683

Last Updated: 2016-12-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 23 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-08-31
• Study Completion Date: 2015-06-30

Brief Summary

This is an open-label pilot study to evaluate the safety, tolerability, and efficacy of IDN-6556 in treating portal hypertension in subjects with liver cirrhosis.

Detailed Description

Studies in patients with liver disease have demonstrated that cCK18 is elevated in the serum of patients and has been associated with disease severity. Studies have also shown that cCK18 is generally elevated to a higher degree in cirrhosis than in other liver diseases. In addition, increasing stages of cirrhosis from Child-Pugh A, Child-Pugh B to Child-Pugh C are associated with progressively higher levels of caspase cleaved cytokeratin 18. This suggests that apoptosis and caspase activity are associated with the severity of disease. IDN-6556 and its ability to inhibit inflammation and apoptosis may have a beneficial impact on both the dynamic and structural components associated with the pathogenesis of portal hypertension in cirrhosis.

Conditions

Liver Cirrhosis; Hepatic Cirrhosis; Portal Hypertension

Keywords

Liver Cirrhosis; Hepatic Cirrhosis; Portal Hypertension

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

IDN-6556 - Overall population

Overall evaluable population treated with IDN-6556 25 mg twice daily

Group Type: EXPERIMENTAL

IDN-6556

Intervention Type: DRUG

25 mg BID

IDN-6556 - Subgroup with Baseline HVPG < 12 mmHg

Subgroup for patients with Baseline HVPG \< 12 mmHg that have been treated with IDN-6556 25 mg twice daily

Group Type: EXPERIMENTAL

IDN-6556

Intervention Type: DRUG

25 mg BID

IDN-6556 - Subgroup Baseline HVPG ≥ 12 mmHg

Subgroup for patients with Baseline HVPG ≥ 12 mmHg that have been treated with IDN-6556 25 mg twice daily

Group Type: EXPERIMENTAL

IDN-6556

Intervention Type: DRUG

25 mg BID

Interventions

IDN-6556

25 mg BID

Intervention Type: DRUG

Other Intervention Names

emricasan; PF-013491390

Eligibility Criteria

Inclusion Criteria

• Male or female subjects of minimum adult legal age (according to local laws for signing the informed consent document), able to provide written informed consent, and able to understand and willing to comply with the requirements of the study
• Clinical, radiological, or biochemical evidence of liver cirrhosis
• Evidence of portal hypertension as evidenced by any of the following:

1. Splenomegaly, on imaging and/or clinical evaluation, with platelet count of <120,000 at study entry, or

2. Presence of small sized varices on screening endoscopy and/or collateral circulation on imaging, or

3. Presence of medium/large varices that have never bled and have been obliterated with endoscopic ligation

• Portal hypertension defined as a hepatic venous pressure gradient (HVPG) >5 mmHg at Screening
• Willingness to utilize two reliable forms of contraception (for both males and females of childbearing potential) from Screening to one month after the last dose of study drug.

Exclusion Criteria

• Decompensated cirrhosis as defined by the presence of overt ascites (requiring diuretics), overt encephalopathy (requiring specific therapy), or history of variceal hemorrhage.
• Known infection with HIV
• Hepatic failure defined as total bilirubin ≥12 mg/dL
• Other non-liver organ failure, including:

1. Renal failure defined as creatinine ≥ 2.0 mg/dL

2. Cerebral failure defined as hepatic encephalopathy grade III or IV

3. Coagulation failure defined as INR ≥ 2.5 or platelets ≤ 20x109/L

4. Hemodynamic requirement for inotropic support

• Child-Pugh score of 10-15 (Child-Pugh C classification)
• Use of vasoactive drugs (at or within 3 months of Screening) that may impair hepatic blood flow; examples include but are not limited to:

1. β-blockers, including carvedilol

2. Nitrates

3. Vasopressin (or analogues)

4. Phosphodiesterase inhibitors (prescribed daily for pulmonary hypertension; p.r.n. use for erectile dysfunction is permitted)

• Change in dose or regimen within 3 months of Screening of:

1. Fibrates or statins

2. Angiotensin II receptor antagonist or angiotensin converting enzyme (ACE) inhibitor

• Use of the following drugs within 2 months of Screening:

1. Systemic corticosteroids

2. Pentoxifylline

3. Known or suspected use of illicit drugs or drugs of abuse (allowed if medically prescribed or indicated)

• Concomitant pancreatitis
• Evidence of portal vein thrombosis on Doppler ultrasound of the portal vasculature
• Active inflammatory bowel disease
• Diagnosed or suspected systemic lupus erythematosus (SLE) and/or rheumatoid arthritis (RA)
• Autoimmune hepatitis
• Hepatitis C Virus (HCV) infected subjects receiving or planning on receiving anti-viral therapy during the course of the study
• Hepatitis B Virus (HBV) infected subjects who have been on stable anti-HBV therapy for less than 3 months
• Hepatocellular carcinoma (HCC) at entry into the study
• Active non-liver malignancies other than curatively treated skin cancer (basal cell or squamous cell carcinomas)
• History or presence of clinically concerning cardiac arrhythmias, or prolongation of screening (pre-treatment) QT or QTc interval of >480 milliseconds (msec)
• Significant systemic or major illness other than liver disease, including coronary artery disease, cerebrovascular disease, pulmonary disease, renal failure, serious psychiatric disease, that, in the opinion of the Investigator would preclude the subject from participating in and completing the study
• Any subject that has received any investigational drug or device within 30 days of dosing or who is scheduled to receive another investigational drug or device in the course of the study
• If female, known pregnancy, or has a positive urine or serum pregnancy test, or lactating/breastfeeding.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Conatus Pharmaceuticals Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

David Hagerty, MD

Role: STUDY_CHAIR

Conatus Pharmaceuticals Inc.

Locations

VA Connecticut Healthcare System

West Haven, Connecticut, United States

Johns Hopkins Sibley Memorial Hospital

Washington D.C., District of Columbia, United States

University of Miami

Miami, Florida, United States

Johns Hopkins Hospital

Baltimore, Maryland, United States

University of Mississippi Medical Center

Jackson, Mississippi, United States

Rutgers New Jersey Medical School

Newark, New Jersey, United States

North Shore University Hospital

Manhasset, New York, United States

New York University Lagone Medical Center

New York, New York, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Albert Einstein Medical Center

Philadelphia, Pennsylvania, United States

St. Luke's Health Baylor College of Medicine

Houston, Texas, United States

University of Texas Health Science Center at Houston

Houston, Texas, United States

University of Utah Hospital

Salt Lake City, Utah, United States

Bon Secours Mary Immaculate Hospital

Newport News, Virginia, United States

Bon Secours St. Mary's Hospital

Richmond, Virginia, United States

McGuire DVAMC

Richmond, Virginia, United States

Countries

United States

Other Identifiers

IDN-6556-11

Identifier Type: -

Identifier Source: org_study_id