Trial Outcomes & Findings for Epidemiology of Acute Kidney Injury in England - 1998 to 2013 (NCT NCT02216695)

NCT ID: NCT02216695

Last Updated: 2016-12-09

Results Overview

A retrospective cohort study of patients with acute kidney injury in England over a period of fifteen years, describing the trends in the mortality of acute kidney injury.

• Recruitment status: COMPLETED
• Target enrollment: 64882 participants
• Primary outcome timeframe: Participants will be followed for the duration of hospital stay (average of 15 days)
• Results posted on: 2016-12-09

Participant Flow

The recruitment was from Hospital episode statistic dataset

Participant milestones

Measure	Acute Kidney Injury All patients who had acute kidney injury requiring dialysis between 1998 and 2013 were identified from hospital episode statistic
Overall Study STARTED	64882
Overall Study COMPLETED	64882
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Epidemiology of Acute Kidney Injury in England - 1998 to 2013

Baseline characteristics by cohort

Measure	Acute Kidney Injury n=64882 Participants we analysed acute kidney injury requiring dialysis in England
Age, Continuous	59.7 years n=93 Participants
Gender Female	24859 Participants n=93 Participants
Gender Male	40023 Participants n=93 Participants
Region of Enrollment United Kingdom	64882 participants n=93 Participants
AKI identified by ICD10 codes of N17	64882 participants n=93 Participants

PRIMARY outcome

Timeframe: Participants will be followed for the duration of hospital stay (average of 15 days)

A retrospective cohort study of patients with acute kidney injury in England over a period of fifteen years, describing the trends in the mortality of acute kidney injury.

Outcome measures

Measure	1998-03 n=4268 Participants All patients who had acute kidney injury and required dialysis between 1998 and 2013 were identified from hospital episode statistic.Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)	2003-08 n=12434 Participants Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)	2008-13 n=48180 Participants Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)
Secular Trends in the Mortality After Acute Kidney Injury From 1998 to 2013	1296 participants	3763 participants	19793 participants

PRIMARY outcome

Timeframe: 15-years

The population incidence of acute kidney injury requiring dialysis (AKI-D) was calculated using mid-year population of England in each year from 1998 to 2013 and expressed as people per million population. This was calculated by dividing number of cases by mid year population of England and multiplying by million.

Outcome measures

Measure	1998-03 n=64882 Participants All patients who had acute kidney injury and required dialysis between 1998 and 2013 were identified from hospital episode statistic.Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)	2003-08 Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)	2008-13 Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)
Incidence of AKI-D From 1998-9 to 2012-13 2004-05	1398 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2005-06	1551 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 1998-99	774 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 1999-00	807 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2000-01	793 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2001-02	914 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2002-03	980 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2003-04	1172 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2006-07	2465 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2007-08	5848 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2008-09	6973 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2009-10	8443 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2010-11	10153 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2011-12	11447 cases per million population	—	—
Incidence of AKI-D From 1998-9 to 2012-13 2012-13	11164 cases per million population	—	—

SECONDARY outcome

Timeframe: Participants will be followed for the duration of hospital stay (average 13 days)

The secondary objective is evaluate factors affecting mortality due to acute kidney injury in the fifteen year period between 1998 and 2013.

Outcome measures

Measure	1998-03 n=64882 Participants All patients who had acute kidney injury and required dialysis between 1998 and 2013 were identified from hospital episode statistic.Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)	2003-08 Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)	2008-13 Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)
Mortality From Acute Kidney Injury in Each Age Group From 1998 to 2013 Less than 65 years	8271 participants	—	—
Mortality From Acute Kidney Injury in Each Age Group From 1998 to 2013 65 to 74 years	7030 participants	—	—
Mortality From Acute Kidney Injury in Each Age Group From 1998 to 2013 75 to 84 years	7959 participants	—	—
Mortality From Acute Kidney Injury in Each Age Group From 1998 to 2013 More than or equal to 85 years	1592 participants	—	—

SECONDARY outcome

Timeframe: Participants will be followed for the duration of hospital stay (average 13 days)

The secondary objective is evaluate factors affecting mortality due to acute kidney injury in the fifteen year period between 1998 and 2013.

Outcome measures

Measure	1998-03 n=64882 Participants All patients who had acute kidney injury and required dialysis between 1998 and 2013 were identified from hospital episode statistic.Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)	2003-08 Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)	2008-13 Data during the 15-year period were divided into three 5-year periods (April 1988 to March 2003, April 2003 to March 2008 and April 2008 to March 2013)
Mortality From Acute Kidney Injury in Each Five-year Period From 1998 to 2013 1998-2003	1296 participants	—	—
Mortality From Acute Kidney Injury in Each Five-year Period From 1998 to 2013 2003-2008	3763 participants	—	—
Mortality From Acute Kidney Injury in Each Five-year Period From 1998 to 2013 2008-2013	19793 participants	—	—

Adverse Events

Dialysis Requiring AKI

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Nitin V Kolhe

Derby Teaching Hospital NHS Trust

Phone: 01332788266

Email: nitin.kolhe@nhs.net

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place