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Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects

NCT ID: NCT02212821

Last Updated: 2016-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-09-30

Brief Summary

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The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.

Detailed Description

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Conditions

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Healthy Volunteers

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Placebo

intravenous infusion

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

physiological saline

Erythromycin

intravenous infusion

Group Type EXPERIMENTAL

Erythromycin

Intervention Type DRUG

Interventions

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Erythromycin

Intervention Type DRUG

Placebo

physiological saline

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Female only.
* Age \> 18 and \< 60.
* Body Mass Index (BMI) of 19-25 kg/m2 (no weight change of more than 5 kg in the past three months).
* Not known to have any chronic medical illness or illnesses affecting the gastrointestinal, cardiovascular, or nervous systems, chronic pain or psychiatric disorder.
* If female not known to be pregnant.
* Not known to have any past upper gastrointestinal surgery.

Exclusion Criteria

* Alcohol consumption \> 7 drinks / week
* Major depression and chronic health conditions except controlled hypertension
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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KU Leuven

OTHER

Sponsor Role collaborator

Universitaire Ziekenhuizen KU Leuven

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jan Tack

Role: PRINCIPAL_INVESTIGATOR

University of Leuven

Other Identifiers

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Erythromycin_v6

Identifier Type: -

Identifier Source: org_study_id