Defining Remission With Etanercept in AS in Real Life Clinical Practice

NCT ID: NCT02202850

Last Updated: 2018-11-30

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

84 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-08-12

Study Completion Date

2017-04-26

Brief Summary

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Determine which remission criterion at Month 6 predicts remission at Month 12 the best.

Detailed Description

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The analysis of the primary endpoint will be based on a logistic regression defining the dependent variable as the remission at Month 12 and the 6 independent variables as ASAS partial remission, ASAS 5/6, ASAS60, ASAS40, BASDAI50 and ASDAS inactive disease status.

This analysis will be conducted in each arm of the study as well as after a pooling of both patient groups.

In this context it seems reasonable to ensure the completion of the study by a total approximate number of 100 patients (approximately 50 patients per arm). In order to ensure 50 completers in each arm, 70 patients will be recruited at baseline, taking into account a drop-out rate of 30% over 1 year period.

Conditions

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Ankylosing Spondylitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Etanercept First

Adults patients with AS receiving Etanercept as first biologic, according to prevailing reimbursement criteria in Belgium

etanercept

Intervention Type DRUG

etanercept 1 x 50 mg/week or 2 x 25mg/week

Etanercept second

Adults patients with AS receiving Etanercept as second biologic, according to prevailing reimbursement criteria in Belgium

etanercept

Intervention Type DRUG

etanercept 1 x 50 mg/week or 2 x 25mg/week

Interventions

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etanercept

etanercept 1 x 50 mg/week or 2 x 25mg/week

Intervention Type DRUG

etanercept

etanercept 1 x 50 mg/week or 2 x 25mg/week

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Patients with AS who start treatment with Etanercept according to prevailing reimbursement criteria and dosing in line with SmPC.

1. First cohort: Etanercept is the first biological product prescribed
2. Second cohort: Etanercept is the second biological product prescribed
2. Capable of understanding and willing to provide signed and dated written, voluntary informed consent before any protocol-specific procedures are performed.
3. 18 years of age or older at time of consent
4. Evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study.

Exclusion Criteria

1\. History of or current psychiatric illness that would interfere with the subject's ability to comply with protocol requirements or to give informed consent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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CHU Brugmann - Site Horta

Brussels, Bruxelles-capitale, Région de, Belgium

Site Status

ASZ Aalst

Aalst, , Belgium

Site Status

Algemeen Stedelijk Ziekenhuis

Aalst, , Belgium

Site Status

Onze Lieve Vrouw Ziekenhuis Aalst

Aalst, , Belgium

Site Status

Onze Lieve Vrouw Ziekenhuis

Aalst, , Belgium

Site Status

Private Practice

Braine-l'Alleud, , Belgium

Site Status

CHIREC

Brussels, , Belgium

Site Status

CHU St-Pierre

Brussels, , Belgium

Site Status

Private Practice

Champion, , Belgium

Site Status

AZ Sint Blasius

Dendermonde, , Belgium

Site Status

Private Practice

Flemalles Haute, , Belgium

Site Status

Biomedical Research Institute/ Department of Rheumatology

Genk, , Belgium

Site Status

Private Practice Rheumatology

Genk, , Belgium

Site Status

ReumaClinic

Genk, , Belgium

Site Status

Reumatologie Associatie

Genk, , Belgium

Site Status

Private Practice

Genk, , Belgium

Site Status

Universitair Ziekenhuis Gent

Ghent, , Belgium

Site Status

Grand Hopital de Charleroi

Gilly, , Belgium

Site Status

Private Practice

Grand-Manil, , Belgium

Site Status

AZ Groeninge Campus Sint Maarten

Kortrijk, , Belgium

Site Status

CHU de Liège

Liège, , Belgium

Site Status

Private Practice of Dr. Geert Ghyselen

Lokeren, , Belgium

Site Status

Louisastraat 18

Mechelen, , Belgium

Site Status

Hôpital Sainte Thérèse/ Department of Rheumatology

Montignies-sur-Sambre, , Belgium

Site Status

Rheumatology

Ostend, , Belgium

Site Status

Office of Maenaut Kristien

Schoten, , Belgium

Site Status

Rheumatology

Sijsele-Damme, , Belgium

Site Status

Sint-Andries Ziekenhuis

Tielt, , Belgium

Site Status

Cliniques Universitaires UCL de Mont-Godinne

Yvoir, , Belgium

Site Status

Countries

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Belgium

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Related Links

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Other Identifiers

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B1801379

Identifier Type: OTHER

Identifier Source: secondary_id

REACH-AS

Identifier Type: OTHER

Identifier Source: secondary_id

B1801379

Identifier Type: -

Identifier Source: org_study_id

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