Open-Label Safety Study of ADS-5102 in PD Patients With LID

NCT ID: NCT02202551

Last Updated: 2020-10-06

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

223 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-07-31

Study Completion Date

2018-02-28

Brief Summary

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This is a 105-week open-label study to evaluate the safety and tolerability of ADS-5102 oral capsules, an extended release formulation of amantadine, in Parkinson's Disease (PD) patients with Levodopa Induced Dyskinesia (LID).

Detailed Description

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Participation in this study was offered to subjects who were described by one of the following 3 groups:

* Group 1: Subjects who completed an Adamas efficacy study evaluating ADS-5102 in LID and chose to immediately transition into the current study without a time gap; this group was subdivided into Group 1A, consisting of subjects who received ADS-5102 in the previous Adamas efficacy study, and Group 1P, consisting of subjects who received placebo in the previous Adamas efficacy study
* Group 2: Subjects who completed a previous Adamas efficacy study evaluating ADS-5102 in LID and entered the current study with a time gap
* Group 3: Subjects who would have been deemed ineligible for participation in a previous Adamas efficacy study due to having undergone DBS

Consented subjects who completed Screening (Visit 1) and met study eligibility criteria were to have a Baseline Visit and receive study drug. During Week 1, subjects took 170 mg of ADS-5102 (1 capsule) daily at bedtime. For Week 2, the dose was increased to 340 mg (2 capsules) daily at bedtime; this dose was to continue through Week 100. During the final week (Week 101) of the study, the ADS-5102 dose was reduced to 170 mg (1 capsule) daily at bedtime. Subjects were enrolled into the study at Visit 2 (Baseline/Week 0) and were to return to the clinic after 4, 8, 16, 28, 40, 52, 64, 76, 88, and 100 weeks of study drug dosing. Subjects were to receive a telephone reminder at the end of Week 1 to increase their dose during Week 2. At the Week 100 Visit, subjects were instructed to reduce their dose to 1 capsule daily at bedtime for 1 week. The amount of available, unused drug was assessed during the Week 100 Visit; subjects were given an additional bottle of study drug, if needed, to complete the 1 week of reduced dosing.

Efficacy, as measured with the MDS-UPDRS, was to be evaluated at all study visits, beginning with the Screening Visit, and excluding the Baseline and Week 4 Visits. A Safety Follow-up Visit was to occur approximately 2 weeks following the completion of treatment. AEs were recorded beginning with the first dose of study drug and continued through the Safety Follow-up Visit. Concomitant medications were recorded throughout the study.

Conditions

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Dyskinesia Levodopa Induced Dyskinesia (LID) Parkinson's Disease (PD)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ADS-5102

amantadine HCl extended release

Group Type EXPERIMENTAL

ADS-5102

Intervention Type DRUG

Interventions

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ADS-5102

Intervention Type DRUG

Other Intervention Names

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amantadine HCl extended release

Eligibility Criteria

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Inclusion Criteria

* Signed a current IRB/REB/IEC-approved informed consent form
* Completed all study visits in previous Adamas efficacy study or were ineligible for participation in previous Adamas studies due to having undergone prior deep brain stimulation.
* Parkinson's disease, per UK Parkinson's Disease Society (UKPDS) Brain Bank Clinical Diagnostic Criteria
* On a stable regimen of antiparkinson's medications at least 30 days prior to screening, including a levodopa preparation administered not less than three times daily.
* History of peak dose dyskinesia that might benefit from specific dyskinesia treatment in the judgment of the subject and clinical investigator

Exclusion Criteria

* Discontinued ADS-5102 in previous Adamas efficacy study due to intolerable or unacceptable AEs considered to be related to ADS-5102
* History of neurosurgical intervention related to Parkinson's disease, with the exception of deep brain stimulation
* History of seizures since completion of participation in previous Adamas studies or within 2 years
* History of stroke or TIA since completion of participation in previous Adamas studies or within 2 years
* History of cancer since completion of participation in previous Adamas studies or within 2 years, with the following exceptions: adequately treated non-melanomatous skin cancers, localized bladder cancer, non-metastatic prostate cancer or in situ cervical cancer
* Presence of cognitive impairment, as evidenced by a Mini-Mental Status Examination (MMSE) score of less than 24 during screening
* If female is pregnant or lactating
* If a sexually active female, is not surgically sterile or at least 2 years post-menopausal, or does not agree to utilize an effective method of contraception from screening through at least 4 weeks after the completion of study treatment.
* Treatment with an investigational drug (other than ADS-5102) or device within 30 days prior to screening
* Treatment with an investigational biologic within 6 months prior to screening
* Current or planned participation in another interventional clinical trial
Minimum Eligible Age

30 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Adamas Pharmaceuticals, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials Director

Role: STUDY_DIRECTOR

Adamas Pharmaceuticals, Inc.

Locations

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Birmingham, Alabama, United States

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Phoenix, Arizona, United States

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Scottsdale, Arizona, United States

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Sun City, Arizona, United States

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Fountain Valley, California, United States

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Pasadena, California, United States

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Reseda, California, United States

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Sacramento, California, United States

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Sunnyvale, California, United States

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Torrance, California, United States

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Ventura, California, United States

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Aurora, Colorado, United States

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Manchester, Connecticut, United States

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Boca Raton, Florida, United States

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Gainesville, Florida, United States

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Jacksonville, Florida, United States

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Naples, Florida, United States

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Port Charlotte, Florida, United States

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Sunrise, Florida, United States

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Tampa, Florida, United States

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Tampa, Florida, United States

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Weston, Florida, United States

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Atlanta, Georgia, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Des Moines, Iowa, United States

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Kansas City, Kansas, United States

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Baltimore, Maryland, United States

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Elkridge, Maryland, United States

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Boston, Massachusetts, United States

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Bingham Farms, Michigan, United States

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West Bloomfield, Michigan, United States

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Golden Valley, Minnesota, United States

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St Louis, Missouri, United States

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Albany, New York, United States

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Commack, New York, United States

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New York, New York, United States

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New York, New York, United States

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New York, New York, United States

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Greensboro, North Carolina, United States

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Raleigh, North Carolina, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Toledo, Ohio, United States

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Tulsa, Oklahoma, United States

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Hershey, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Roanoke, Virginia, United States

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Kirkland, Washington, United States

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Morgantown, West Virginia, United States

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Milwaukee, Wisconsin, United States

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Innsbruck, , Austria

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Vienna, , Austria

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Vienna, , Austria

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Edmonton, Alberta, Canada

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Toronto, Ontario, Canada

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Regina, Saskatchewan, Canada

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Bordeaux, , France

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Bron, , France

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Clermont-Ferrand, , France

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Lille, , France

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Marseille, , France

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Montpellier, , France

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Poitiers, , France

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Rennes, , France

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Rouen, , France

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Strasbourg, , France

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Toulouse, , France

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München, Bavaria, Germany

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München, Bavaria, Germany

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Beelitz-Heilstätten, Brandenburg, Germany

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Göttingen, Lower Saxony, Germany

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Leipzig, Saxony, Germany

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Gera, Thuringia, Germany

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Stadtroda, Thuringia, Germany

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Berlin, , Germany

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Berlin, , Germany

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Hamburg, , Germany

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Kassel, , Germany

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Marburg, , Germany

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Barcelona, , Spain

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Barcelona, , Spain

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Barcelona, , Spain

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Barcelona, , Spain

Site Status

Countries

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United States Austria Canada France Germany Spain

References

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Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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ADS-AMT-PD302

Identifier Type: -

Identifier Source: org_study_id

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