Fatty Acids and Executive Function Development in 7-12 Year Olds

NCT ID: NCT02199808

Last Updated: 2020-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

79 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-04-30

Study Completion Date

2016-05-31

Brief Summary

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Purpose: To examine the effect of the omega-6 to omega-3 fatty acid ratio on age-related changes in executive functions in children and older adults.

Participants: Eighty-four typically-developing 7-to 12-year-old children.

Procedure (methods): Participants and a caregiver will participate in 4 sessions. Three sessions will consist of the screening. These sessions will be telephone calls to collect 24-hour diet information that will be used to determine whether they are eligible for the fourth session. Approximately 120 participants will be screened to find 84 participants who are eligible for the fourth session, in which participants will complete a series of tests on the Cambridge Neuropsychological Test Automated Battery (CANTAB) - a touch-screen device that provides computerized versions of standardized cognitive tests. They will also complete a maze task in which they figure out a path through the maze by walking on the correct squares. Brain activity will be recorded using a portable near-infrared spectroscopy (NIRS) system.

Detailed Description

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Conditions

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Executive Function

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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7-9 year olds

These are children who are between 7 and 9 years old when they are tested.

No interventions assigned to this group

10-12 year olds

These are children who are between 10 and 12 years old when they are tested.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Typically-developing children 7-12 years old

Exclusion Criteria

* Children or parents who do not speak English
* Any diagnosis of a psychological illness
* History of seizures
* History of tobacco exposure during gestation
* History of alcohol exposure during gestation
Minimum Eligible Age

7 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sigma Xi

UNKNOWN

Sponsor Role collaborator

University of North Carolina, Chapel Hill

OTHER

Sponsor Role lead

Responsible Party

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Carol Cheatham, PhD

Associate Professor of Psychology & Neuroscience

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Carol L Cheatham, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of North Carolina, Chapel Hill

Locations

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UNC-Chapel Hill's Nutrition Research Institute

Kannapolis, North Carolina, United States

Site Status

Countries

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United States

References

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Ingol TT, Li R, Boone KM, Rausch J, Klebanoff MA, Turner AN, Yeates KO, Nelin MA, Sheppard KW, Keim SA. Docosahexaenoic and Arachidonic Acid Supplementation of Toddlers Born Preterm Does Not Affect Short-Term Growth or Adiposity. J Nutr. 2019 Dec 1;149(12):2182-2190. doi: 10.1093/jn/nxz115.

Reference Type DERIVED
PMID: 31187863 (View on PubMed)

Sheppard KW, Cheatham CL. Omega-6/omega-3 fatty acid intake of children and older adults in the U.S.: dietary intake in comparison to current dietary recommendations and the Healthy Eating Index. Lipids Health Dis. 2018 Mar 9;17(1):43. doi: 10.1186/s12944-018-0693-9.

Reference Type DERIVED
PMID: 29523147 (View on PubMed)

Sheppard KW, Cheatham CL. Executive functions and the omega-6-to-omega-3 fatty acid ratio: a cross-sectional study. Am J Clin Nutr. 2017 Jan;105(1):32-41. doi: 10.3945/ajcn.116.141390. Epub 2016 Nov 16.

Reference Type DERIVED
PMID: 27852615 (View on PubMed)

Other Identifiers

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14-0198

Identifier Type: -

Identifier Source: org_study_id