Xentuzumab (BI 836845) Plus Afatinib in Patients With Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)

NCT ID: NCT02191891

Last Updated: 2025-06-25

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 32 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-10-21
• Study Completion Date: 2018-04-18

Brief Summary

Part A: To determine the maximum tolerated dose (MTD) and/or recommended phase II dose (RP2D) of Xentuzumab (BI 836845) in combination with afatinib in patients with non-small cell lung cancer with progression following prior treatment (EGFR TKI or platinum-based chemotherapy).

Part B: To evaluate the early anti-tumour activity of Xentuzumab (BI 836845) in combination with afatinib in patients with EGFR mutant non-small cell lung cancer with progression following prior irreversible EGFR TKIs.

Part A and B: To evaluate the safety and pharmacokinetics of BI 836845 in combination with afatinib in patients with non-small cell lung cancer

Conditions

Carcinoma, Non-Small-Cell Lung

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Xentuzumab + Afatinib 30 milligram (mg) - Part A

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib 30 mg film-coated tablet. Dose confirmation part (Part A).

Group Type: EXPERIMENTAL

Xentuzumab

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Afatinib

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Xentuzumab + Afatinib 40 mg - Part A

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib 40 mg film-coated tablet. Dose confirmation part (Part A).

Group Type: EXPERIMENTAL

Xentuzumab

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Afatinib

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Xentuzumab + Afatinib 20 mg - Part B

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib 20 mg film-coated tablet. Expansion part (Part B).

Group Type: EXPERIMENTAL

Xentuzumab

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Afatinib

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Xentuzumab + Afatinib 30 mg - Part B

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib 30 mg film-coated tablet. Expansion part (Part B).

Group Type: EXPERIMENTAL

Xentuzumab

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Afatinib

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Xentuzumab + Afatinib 40 mg - Part B

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib 40 mg film-coated tablet. Expansion part (Part B).

Group Type: EXPERIMENTAL

Xentuzumab

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Afatinib

Intervention Type: DRUG

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Interventions

Xentuzumab

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Intervention Type: DRUG

Afatinib

Patients received intravenous infusion of Xentuzumab 1000 milligram (mg) delivered over 60 minutes per week for 4 weeks, in combination with once daily oral treatment of Afatinib film-coated tablet.

Intervention Type: DRUG

Other Intervention Names

BI 836845

Eligibility Criteria

Inclusion Criteria

• Aged 18 years or older
• Pathologically confirmed of advanced and/or metastatic stage IIIb/IV non-small cell carcinoma of lung
• Activating EGFR mutation (exon 19 deletion, L858R, G719X, L861X)
• Presence of EGFR activating mutation and absence of EGFR T790M in the tumour associated with the latest disease progression. Only applicable in Part B
• Must have adequate fresh or archival tumour tissue at the late disease progression immediately prior to the study entry
• Part A: Progression of disease (RECIST 1.1) while on continuous treatment with single EGFR TKI or for histology other than adenocarcinoma and without prior EGFR TKI treatment: progression of disease (RECIST v1.1) on platinum-based chemotherapy. Part B: Progression of disease (RECIST v1.1) while on continuous treatment with single agent of the second generation irreversible EGFR TKI (e.g. afatinib or dacomitinib)
• No intervening systemic therapy between cessation of EGFR TKI and study treatment
• Patient must have measurable disease per RECIST 1.1 presented after tumour biopsy for the late disease progression
• Eastern Cooperative Oncology Group (ECOG) performance score 0 or 1
• Life expectancy of >= 3 months
• Fasting plasma glucose < 8.9 mmol/L (< 160mg/dL) and HbA1C < 8%
• Adequate organ function
• Recovered from any previous therapy related toxicity to <= Grade 1 at study entry (except for stable sensory neuropathy <= Grade 2 and alopecia)
• Written informed consent that is consistent with ICH-GCP guidelines and local regulations
• No known potentially targetable mutation other than IGF signaling pathway or EGFR or no available treatment for potentially targetable mutation

Exclusion Criteria

• Part A only: For patient who has been treated with afatinib: last treatment at reduced dose below the assigned dose level
• Patient whose disease progressed on insufficient dose of EGFR TKI immediately prior to study in the opinion of the investigator
• More than 2 prior EGFR TKI treatment regimens for Part B
• Chemotherapy, biological therapy or investigational agents (except EGFR TKIs) within 4 weeks
• Use of previous EGFR TKIs except afatinib within 3 days
• Radiotherapy within 4 weeks prior to the start of study treatment
• Active brain or subdural metastases
• Meningeal carcinomatosis.
• Major surgery (as judged by the investigator) within 4 weeks
• Known hypersensitivity to afatinib, monoclonal antibody
• Prior severe infusion-related reaction to a monoclonal antibody
• History or presence of clinically relevant cardiovascular abnormalities
• Female patients of childbearing potential (see Section 4.2.2.3) and male who are able to father a child
• Any history of or concomitant condition that, in the opinion of the investigator not to comply with the study or interfere with the evaluation of the efficacy and safety of the test drug
• Previous or concomitant malignancies at other sites, except effectively treated non-melanoma skin cancers, carcinoma in situ of the cervix, ductal carcinoma in situ or effectively treated malignancy that has been in remission for more than 3 years and is considered to be cured.
• Disease that is considered by the investigator to be rapidly progressing or life threatening such as extensive symptomatic visceral disease including hepatic involvement and pulmonary lymphangitic spread of tumour (subjects who are intended for urgent chemotherapy)
• Requiring treatment with any of the prohibited concomitant medications
• Known pre-existing interstitial lung disease (ILD)
• Any history or presence of poorly controlled gastrointestinal disorders that could affect the absorption of the study drug
• Active hepatitis B infection active hepatitis C infection and/or known HIV carrier.
• Previous treatment with agents targeting the insulin like growth factor (IGF) signalling pathway.
• Previous treatment with EGFR TKI which cannot be documented as either reversible or irreversible (Part B only)
• Part B only: Prior treatment with third generation irreversible EGFR TKI (e.g. AZD9291 or CO-1686)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Boehringer Ingelheim

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Boehringer Ingelheim

Role: STUDY_CHAIR

Boehringer Ingelheim

Locations

National Hospital Organization Kyushu Cancer Center

Fukuoka, Fukuoka, , Japan

National Cancer Centre Singapore

Singapore, , Singapore

Chungbuk National University Hospital

Cheongju-si, , South Korea

Severance Hospital

Seoul, , South Korea

Samsung Medical Center

Seoul, , South Korea

Asan Medical Center

Seoul, , South Korea

Chang Gung Memorial Hospital Chiayi

Chiayi City, , Taiwan

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, , Taiwan

NCKUH

Tainan City, , Taiwan

National Taiwan University Hospital

Taipei, , Taiwan

Countries

Japan; Singapore; South Korea; Taiwan

Provided Documents

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Related Links

https://www.mystudywindow.com

Related Info

Other Identifiers

1280.16

Identifier Type: -

Identifier Source: org_study_id