Leukemia SPORE Phase II DAC Study for R/R and Elderly Acute AML and MDS

NCT ID: NCT02190695

Last Updated: 2021-05-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 92 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-04-01
• Study Completion Date: 2020-04-16

Brief Summary

The purpose of this study is to find a new way to treat Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukemia (CMML). All the drugs are used to treat AML and MDS but are not usually combined together. The investigators are looking at both the safety and Efficacy of each combination.

Detailed Description

Study Groups:

If the participant is found to be eligible to take part in this study and he/she is one of the first 30 participants enrolled, the participant will have an equal chance of being in one of 3 study groups. If the participant enrolls after the first 30 participants are enrolled, he/she will have a higher chance of being assigned to the group is having better results.

• If participant is in Group 1, he/she will receive decitabine alone.
• If participant is in Group 2, he/she will receive decitabine and carboplatin.
• If participant is in Group 3, he/she will receive decitabine and arsenic trioxide.

Study Drug Administration:

Every 4 weeks is a study cycle.

The participant will receive decitabine by vein over about 1 hours on Days 1-5 of each cycle.

If the participant is receiving carboplatin, he/she will receive it over 1 hour on Day 8 (+/-2 days) of each cycle.

If the participant is receiving arsenic trioxide, he/she will receive it over about 1 hour on Days 1-5 of each cycle

Study Visits:

Blood (about 1-2 teaspoons) will be drawn 1-2 times a week during Cycle 1 and then every 2-4 weeks after that for routine tests. If you have stable disease, blood will only be drawn every 4-6 weeks.

On Day 28 of Cycle 3 (+/- 3 days), the participant will have a bone marrow aspirate and biopsy to check the status of the disease. After that, the participant will have bone marrow biopsies/aspirations when the doctor thinks it is needed.

If the participant is in Group 3, he/she will have EKGs on Day 1 of each cycle before receiving the study drugs. On Days 1 and 4 of each cycle, blood (about 1-2 teaspoons) will also be drawn for routine tests before their dose of the study drugs.

If the participant is taken off study, blood (about 1-2 teaspoons) will be drawn for routine tests.

Length of Study:

The participant may continue taking the study drugs for as long as the doctor thinks it is in your best interest. The participant will no longer be able to take the study drug(s) if the disease gets worse, if intolerable side effects occur, or if he/she is unable to follow study directions.

This is an investigational study. Arsenic trioxide is FDA approved and commercially available for the treatment of APL. Decitabine is FDA approved and commercially available for the treatment of MDS. Carboplatin is FDA approved and commercially available for the treatment solid tumors. The study drug or study drug combination the participant receives on this study are considered investigational.

Conditions

Acute Myeloid Leukemia; Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Decitabine

Decitabine 20mg/m2 IV over 1hour daily times 5 days every 28 days

Group Type: ACTIVE_COMPARATOR

Decitabine

Intervention Type: DRUG

20 mg/m2 by vein daily over 1 hour on Days 1-5 of each 28 day cycle.

Decitabine and Carboplatin

Decitabine 20mg/m2 IV over 1hour daily times 5 days, plus Carboplatin AUC 5 IV over 1hour on day 8. repeat every 28 days.

Group Type: EXPERIMENTAL

Decitabine

Intervention Type: DRUG

20 mg/m2 by vein daily over 1 hour on Days 1-5 of each 28 day cycle.

Carboplatin

Intervention Type: DRUG

AUC 5 by vein over 1 hour on Day 8 of each 28 day cycle.

Decitabine and Arsenic

Decitabine 20mg/m2 IV over 1 hour daily for 5 days plus Arsenic Trioxide 0.15mg/kg IV daily for 5 days. repeat every 28 days

Group Type: EXPERIMENTAL

Decitabine

Intervention Type: DRUG

20 mg/m2 by vein daily over 1 hour on Days 1-5 of each 28 day cycle.

Arsenic trioxide

Intervention Type: DRUG

0.15 mg/kg by vein over 1 hour on Days 1-5 of each 28 day cycle.

Interventions

Decitabine

20 mg/m2 by vein daily over 1 hour on Days 1-5 of each 28 day cycle.

Intervention Type: DRUG

Carboplatin

AUC 5 by vein over 1 hour on Day 8 of each 28 day cycle.

Intervention Type: DRUG

Arsenic trioxide

0.15 mg/kg by vein over 1 hour on Days 1-5 of each 28 day cycle.

Intervention Type: DRUG

Other Intervention Names

Dacogen; cis-Diammine; Paraplatin; Paraplatin-AQ; ATO

Eligibility Criteria

Inclusion Criteria

1. Patients with AML, relapsed or refractory to standard therapy or elderly patients with AML (age 65 or over). Patients who have AML and are younger than age 65 but considered unfit for conventional chemotherapy are eligible. Patients with de novo or treated MDS or CMML INT-1 or above are eligible. Patients may have had prior exposure to azacitidine but no more than one cycle of decitabine. Patients must have been off chemotherapy for 2 weeks prior to entering this study and have recovered from the toxicities of that therapy; A caveat to this is in the case of rapidly progressive disease. Hydroxyurea is permitted for control of elevated WBC prior to treatment and can be continued for the first 4 weeks of therapy. Erythropoiesis stimulating agents (ESAs) and GCSF are allowed before therapy. ESAs, GCSF or other growth factors are permitted on therapy.

2. Performance 0-2 (ECOG).

3. Adequate cardiac functions assessed by 2D ECHO (NYHA cardiac III-IV excluded).

4. Pre-treatment EKG

5. Adequate end organ function with creatinine </= 2mg/dL and total bilirubin </= 2mg/dL, AST and ALT </= or = 2.5 X institutional ULN.

6. Absence of significant intercurrent illness such as uncontrolled heart failure, unstable angina, cardiac arrhythmia and psychiatric illness which precludes the giving of informed consent.

7. Signed informed consent

Exclusion Criteria

1. Nursing and pregnant females. Patients of childbearing potential should practice effective methods of contraception. Should a woman become preg-nant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.

2. Current uncontrolled infections.

3. Uncontrolled intercurrent illness including, but not limited to, symptomatic congestive heart failure, unstable angina pectoris, or psychiatric illness/social situations that would limit compliance with study requirements.

4. Chronic kidney disease > stage 3.

5. HIV infection.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

M.D. Anderson Cancer Center

OTHER

Sponsor Role: collaborator

Teva Pharmaceuticals USA

INDUSTRY

Sponsor Role: collaborator

Fox Chase Cancer Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Patricia Kropf, MD

Role: PRINCIPAL_INVESTIGATOR

Temple University Health System

Locations

Temple BMT Program at Jeanes Hospital

Philadelphia, Pennsylvania, United States

M.D. Anderson Cancer Center

Houston, Texas, United States

Countries

United States

References

Kropf PL, Chung W, Shameem R, Xiao L, Balch C, Huang X, Issa JJ. A phase 2 study of decitabine with or without carboplatin and arsenic trioxide in patients with MDS and AML. Blood Neoplasia. 2025 Jan 23;2(2):100071. doi: 10.1016/j.bneo.2025.100071. eCollection 2025 May.

Reference Type: DERIVED

PMID: 40453133 (View on PubMed)

Other Identifiers

21357

Identifier Type: -

Identifier Source: org_study_id

NCT02188706

Identifier Type: -

Identifier Source: nct_alias