CD5789 (Trifarotene) Long Term Safety Study on Acne Vulgaris

NCT ID: NCT02189629

Last Updated: 2019-11-14

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

453 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-02-23

Study Completion Date

2017-02-23

Brief Summary

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Multi-center, open-label, non-comparative safety and efficacy study with 52 Weeks of treatment on the face and trunk for acne vulgaris.

Detailed Description

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To determine the safety and efficacy of CD5789 (trifarotene) 50 µg/g cream in the long-term treatment (up to 52 Weeks) of subjects with acne vulgaris. Efficacy will be evaluated as a secondary objective.

Conditions

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Acne Vulgaris

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CD5789 (trifarotene) cream

Group Type EXPERIMENTAL

CD5789 (trifarotene)

Intervention Type DRUG

Interventions

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CD5789 (trifarotene)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* The Subject has a facial acne severity grade of IGA grade 3 (moderate) at Screening and Baseline visits.
* The Subject has a minimum of 20 inflammatory lesions and 25 non-inflammatory lesions at Screening and Baseline visits on the face.

Exclusion Criteria

* The subject has severe forms of acne (acne conglobata, acne fulminans) or secondary acne form (chloracne, drug-induced acne, etc.).
* The Subject has more than 1 nodule on the face at Screening and at Baseline visits.
* The Subject has any acne cyst on the face at Screening and at Baseline visits.
Minimum Eligible Age

9 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Galderma R&D

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kevin Chan

Role: STUDY_DIRECTOR

Galderma R&D

Locations

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Galderma Investigational Site

Mobile, Alabama, United States

Site Status

Galderma Investigational Site

Rogers, Arkansas, United States

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Galderma Investigational Site

Sacramento, California, United States

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Galderma Investigational Site

San Diego, California, United States

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Miami, Florida, United States

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Galderma Investigational Site

Miramar, Florida, United States

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Galderma Investigational Site

Newnan, Georgia, United States

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Galderma Investigational Site

Louisville, Kentucky, United States

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Galderma Investigational Site

Albuquerque, New Mexico, United States

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Galderma Investigational Site

New York, New York, United States

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Galderma Investigational Site

High Point, North Carolina, United States

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Beachwood, Ohio, United States

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Galderma Investigational Site

Portland, Oregon, United States

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Galderma Investigational Site

Knoxville, Tennessee, United States

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Galderma Investigational Site

Chomutov, , Czechia

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Hradec Králové, , Czechia

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Galderma Investigational Site

Olomouc, , Czechia

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Galderma Investigational Site

Pardubice, , Czechia

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Prague, , Czechia

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Galderma Investigational Site

Augsburg, , Germany

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Galderma Investigational Site

Berlin, , Germany

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Galderma Investigational Site

Berlin, , Germany

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Galderma Investigational Site

Dessau, , Germany

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Galderma Investigational Site

Mahlow, , Germany

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Galderma Investigational Site

Münster, , Germany

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Galderma Investigational Site

Wuppertal, , Germany

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Galderma Investigational Site

Balatonfüred, , Hungary

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Galderma Investigational Site

Miskolc, , Hungary

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Galderma Investigational Site

Pécel, , Hungary

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Galderma Investigational Site

Szeged, , Hungary

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Galderma Investigational Site

Szekszárd, , Hungary

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Galderma Investigational Site

Szolnok, , Hungary

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Countries

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United States Czechia Germany Hungary

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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RD.06.SPR.18250

Identifier Type: -

Identifier Source: org_study_id

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