Study of CLR457 Administered Orally in Adult Patients With Advanced Solid Malignancies

NCT ID: NCT02189174

Last Updated: 2021-12-03

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE1
• Total Enrollment: 31 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-08-07
• Study Completion Date: 2015-11-12

Brief Summary

To estimate the maximum tolerated dose (MTD) or recommended dose for phase II (RP2D) of CLR457 and to investigate the anti-tumor activity of CLR457

Conditions

Advanced Solid Tumor

Keywords

Solid tumor,; breast cancer,; lung cancer,; endometrial cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

CLR457

Group Type: EXPERIMENTAL

CLR457

Intervention Type: DRUG

Interventions

CLR457

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Written informed consent must be obtained prior to any screening procedures
• Phase I: Patients with advanced/metastatic solid tumors, with measurable or non-measurable disease as determined by modified RECIST version 1.1 who have progressed despite standard therapy or be intolerant of standard therapy, or for whom no standard therapy exists, who have tumors harboring one of the following: confirmed PIK3CA mutation or amplification, PTEN loss of function, EGFR mutation, cMET activation and/or HER2 overexpression. Endometrial carcinoma will not be selected for any molecular status.
• Phase II: Patients with advanced/metastatic solid tumors, with at least one measurable lesion as determined by modified RECIST version 1.1, who progressed despite standard therapy or be intolerant of standard therapy, or for whom no standard therapy exists, fitting in one of the following groups: Group 1: patients with PIK3CA mutated or amplified ER positive (ER+) breast cancer ; Group 2: patients with endometrial carcinoma (not selected for any molecular status); Group 3: patients with solid tumors (with the exception of PIK3CA mutant/amplified ER+ breast cancer and endometrial carcinoma) harboring PIK3CA mutation or amplification/any PTEN status; Group 4: patients with solid tumors (with the exception of endometrial carcinoma) harboring PTEN loss of function/ PIK3CA wild type; Group 5: non-small cell lung cancer harboring cMET activation and/or EGFR mutation. Up to 3 lines of chemotherapy allowed in advanced/metastatic setting.
• ECOG Performance Status ≤ 2.
• Availability of a representative formalin fixed paraffin embedded tumor tissue sample. If archival tumor sample is not available, a newly obtained tumor sample needs to be submitted instead.

Exclusion Criteria

• Brain metastasis unless treated and neurologically stable
• Patient having out of range laboratory values defined as:

Hepatic and renal function:

• Serum total Bilirubin ≥ 1.5 x ULN (upper limit of normal) or aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≥ 2.5 x ULN
• For patients with tumor involvement of the liver AST or ALT > 5 x ULN
• For patients with Gilbert's syndrome total bilirubin > 2.5 x ULN
• Serum creatinine > 1.5 x ULN and/or measured or calculated creatinine clearance < 75% LLN (lower limit of normal)

Bone marrow function:

• Platelets < 100 x 109/L
• Hemoglobin (Hgb) < 9 g/dL
• Absolute Neutrophil Count (ANC) < 1.5 x 109/L

Cardiac function:

• Clinically significant and/or uncontrolled heart disease such as congestive heart failure (CHF) requiring treatment (NYH grade ≥2), hypertension or arrhythmia
• Left ventricular ejection fraction (LVEF) < 45% as determined by MUGA scan or ECHO
• QTcF >480 msec on screening ECG or congenital long QT syndrome
• Acute myocardial infarction (AMI) or unstable angina pectoris < 3 months prior to study entry

• Peripheral neuropathy CTCAE Grade ≥2
• History of pancreatitis of any grade
• Patients with diabetes mellitus requiring insulin treatment and/or with clinical signs or with Fasting Plasma Glucose (FPG) ≥ 140 mg/dL / 7.8 mmol/L
• Patients receiving treatment with medications that are known to be 1) strong inhibitors or inducers of CYP3A4/5; 2) CYP2C9 substrate with narrow therapeutic index; 3) QT prolonging agents; 4) proton pump inhibitors unless these medications can be discontinued at least a week prior to start of treatment.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Novartis Pharmaceuticals

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

Massachusetts General Hospital SC-9

Boston, Massachusetts, United States

Memorial Sloan Kettering SC-4

New York, New York, United States

Tennessee Oncology SC

Nashville, Tennessee, United States

Novartis Investigative Site

Toronto, Ontario, Canada

Novartis Investigative Site

Kashiwa, Chiba, Japan

Novartis Investigative Site

Singapore, , Singapore

Novartis Investigative Site

Barcelona, Catalonia, Spain

Countries

Australia; Austria; France; Hong Kong; Israel; Italy; Switzerland; United States; Canada; Japan; Singapore; Spain

Other Identifiers

CCLR457X2101

Identifier Type: -

Identifier Source: org_study_id