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The Implementation of Novel 'Heavy' Water Techniques for Determining Modulation of Muscle Protein, DNA and Lipid Synthesis Due to Ageing

NCT ID: NCT02152839

Last Updated: 2015-07-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-05-31

Brief Summary

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Maintenance of body's skeletal muscle is key to a healthy older age. However, as we age we lose on average 1-2% of our muscle each year. In order to slow this loss we need to understand fully the mechanisms regulating muscle mass with ageing. In this project we aim to determine these mechanisms using a new novel technique of 'heavy' water ingestion, which will allow us to measure multiple aspects of skeletal muscle mass control during normal everyday activities in young and old individuals over a period of 6 weeks. We will also determine the influence of resistance exercise training during this period in offsetting declines in muscle with ageing using this method

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Old Unilateral Exercise

Old individuals (65-75y) studied before and after 6 weeks of unilateral resistance exercise training

Group Type EXPERIMENTAL

Resistance Exercise

Intervention Type BEHAVIORAL

6 Weeks progressive unilateral resistance exercise, 3 times per week, 70% 1-RM, 6 x 8 Repetitions. 2 minutes rest between sets

Young Unilateral Exercise

Young Individuals (18-30y) studied before and after 6 weeks unilateral resistance exercise training

Group Type EXPERIMENTAL

Resistance Exercise

Intervention Type BEHAVIORAL

6 Weeks progressive unilateral resistance exercise, 3 times per week, 70% 1-RM, 6 x 8 Repetitions. 2 minutes rest between sets

Interventions

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Resistance Exercise

6 Weeks progressive unilateral resistance exercise, 3 times per week, 70% 1-RM, 6 x 8 Repetitions. 2 minutes rest between sets

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Young (18-30y) and old men (65-75y) who are generally healthy and recreationally active

Exclusion Criteria

* Active cardiovascular disease
* Cerebrovascular disease including previous stroke, aneurysm (large vessel or intracranial)
* Respiratory disease including pulmonary hypertension or COPD
* Hyper/ hypo parathyroidism, hyper/ hypothyroidism, Cushing's disease, diabetes
* Active inflammatory bowel disease
* Renal disease
* Malignancy
* Recent steroid treatment (within 6 mo), or hormone replacement therapy
* Clotting dysfunction
* Musculoskeletal or neurological disorders
* Any disease requiring long-term drug prescriptions, including statins
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Physiological Society

UNKNOWN

Sponsor Role collaborator

University of Nottingham

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Philip Atherton, PhD, AFHEA

Role: PRINCIPAL_INVESTIGATOR

University of Nottingham

Locations

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Royal Derby Hospital Medical School

Derby, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Brook MS, Wilkinson DJ, Tarum J, Mitchell KW, Lund JL, Phillips BE, Szewczyk NJ, Kadi F, Greenhaff PL, Smith K, Atherton PJ. Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle. Geroscience. 2023 Feb;45(1):451-462. doi: 10.1007/s11357-022-00651-y. Epub 2022 Sep 9.

Reference Type DERIVED
PMID: 36083436 (View on PubMed)

Other Identifiers

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Physoc_D20

Identifier Type: -

Identifier Source: org_study_id